Role of the chronic bacterial infection in urinary bladder carcinogenesis
The purpose of this thesis was to determine whether or not bacterial infection of the urinary bladder had a role in urinary bladder carcinogenesis. To investigate this proposition, four separate studies were conducted. The first study developed an experimental animal model where bacterial infection of the urinary bladder could be introduced and maintained for a period in excess of one year. The method of infection, inoculation of bacteria (Escherichia coli type 04) subserosally into the vesical wall, successfully caused persistent infection in the majority of animals. In the second study the temporal effects of bacterial infection on the induction of urothelial ornithine decarboxylase (ODC) and /sup 3/H-thymidine uptake and DNA synthesis were examined. Bacterial infection of the urinary bladder induced urothelial ODC with a peak in enzyme activity 6 hr after infection./sup 3/H-Thymidine uptake and DNA synthesis peaked 48 hr after infection and coincided with the urothelial hyperplasia that occurred in response to the infection. In the third study the specific bladder carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) was given to rats concurrent with the urinary bacterial infection. In the fourth study rats were administered sodium nitrate and either dibutylamine or piperazine in the drinking water. The infected group developed bladder tumors while none were detected in the non-infected rats. From these studies it may be concluded that bacterial infection may have a significant role in the process of urinary bladder carcinogenesis.
- Research Organization:
- Wisconsin Univ., Madison (USA)
- OSTI ID:
- 6518300
- Resource Relation:
- Other Information: Thesis (Ph. D.)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BACTERIAL DISEASES
BIOLOGICAL EFFECTS
TRITIUM COMPOUNDS
UPTAKE
BLADDER
CARCINOGENESIS
DECARBOXYLASES
DISEASE INCIDENCE
DNA REPLICATION
ESCHERICHIA COLI
NITROSAMINES
RATS
THYMIDINE
AMINES
ANIMALS
AZINES
BACTERIA
BODY
CARBON-CARBON LYASES
CARBOXY-LYASES
DISEASES
ENZYMES
HETEROCYCLIC COMPOUNDS
INFECTIOUS DISEASES
LABELLED COMPOUNDS
LYASES
MAMMALS
MICROORGANISMS
NITROSO COMPOUNDS
NUCLEIC ACID REPLICATION
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOGENESIS
PYRIMIDINES
RIBOSIDES
RODENTS
URINARY TRACT
VERTEBRATES
551001* - Physiological Systems- Tracer Techniques