Incidence and pathology of pancreatic carcinoma among atomic bomb survivors, 1950-1982
There is little evidence that pancreatic carcinoma is radiogenic in humans. To further investigate this possibility, all follow-up sources at the Radiation Effects Research Foundation were utilized to identify 378 incident cases of pancreatic cancer which occurred between October 1, 1950 and December 31, 1982 among 91,231 members of the cohort of atomic bomb survivors in Hiroshima and Nagasaki, Japan. An independent pathology review was conducted for all eligible cases, and pathology reports and slides were sought for those having a tissue diagnosis. The incidence of pancreatic carcinoma in this cohort was evaluated with respect to city, sex, age at exposure, time since exposure, radiation dose, and selected pathologic characteristics. Radiation dose effects, as well as spontaneous (background) incidence rates, were estimated using generalized Poisson regression models. Allowing for natural variations in background incidence, a significantly increased risk of pancreatic cancer was found to be associated with atomic bomb radiation exposure (relative risks = 1.3,95% confidence interval = 1.1-1.6). This relationship was much stronger in Nagasaki than Hiroshima, and among males than females. Age at exposure and time since exposure had little effect on radiation risk estimates. The interpretation of these findings in relation to their biologic plausibility is stressed, and the implications of using Radiation Effects Research Foundation incidence data in this regard are discussed.
- Research Organization:
- Fred Hutchinson Cancer Research Center, Seattle, WA
- OSTI ID:
- 6516088
- Report Number(s):
- CONF-860694-; TRN: 87-020365
- Journal Information:
- Am. J. Epidemiol.; (United States), Vol. 124:3; Conference: Conference of the Society for Epidemiologic Research, Pittsburgh, PA, USA, 11 Jun 1986
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
MAN
INJURIES
NUCLEAR EXPLOSIONS
BIOLOGICAL EFFECTS
PANCREAS
NEOPLASMS
RADIATION DOSES
HIROSHIMA
JAPAN
NAGASAKI
PATHOLOGICAL CHANGES
ANIMALS
ASIA
BODY
DIGESTIVE SYSTEM
DISEASES
DOSES
ENDOCRINE GLANDS
EXPLOSIONS
GLANDS
MAMMALS
ORGANS
PRIMATES
VERTEBRATES
560151* - Radiation Effects on Animals- Man