Effect of tyrosine administration on duodenal ulcer induced by cysteamine in the rat
Duodenal ulcers were produced by administering cysteamine to rats. Pretreatment with the catecholamine precursor, L-tyrosine (40 mg/100 g i.p. for 5 days), decreased the intensity of duodenal ulcers induced by cysteamine. Equimolar doses of tyrosine methyl ester (51.2 mg/100 g i.p. or s.c.) were equally effective in reducing ulcer intensity. Other amino acids (i.e., alanine, aspartic acid, glutamic acid, glycine, leucine, lysine, tryptophan and valine) did not prevent experimental duodenal ulcers. Coadministration of other large neutral amino acids (e.g., leucine and valine) that compete with tyrosine for uptake into the brain did not inhibit the effect of tyrosine on duodenal ulcers induced by cysteamine. Gastric, duodenal and brain dopamine concentrations were increased 1 hr after the injection of tyrosine methyl ester (25.6 mg/100 g s.c.). These results suggest that the effect of tyrosine on duodenal ulcer induced by cysteamine may be mediated by changes in gastrointestinal dopamine metabolism.
- Research Organization:
- Brigham and Women's Hospital, Boston, MA
- OSTI ID:
- 6515688
- Journal Information:
- J. Pharmacol. Exp. Ther.; (United States), Vol. 3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
MEA
TOXICITY
TYROSINE
BIOLOGICAL EFFECTS
ULCERS
PATHOGENESIS
AMINO ACIDS
DOPAMINE
METABOLISM
RADIOPROTECTIVE SUBSTANCES
RATS
SMALL INTESTINE
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BODY
CARBOXYLIC ACIDS
CARDIOTONICS
CARDIOVASCULAR AGENTS
DIGESTIVE SYSTEM
DRUGS
GASTROINTESTINAL TRACT
HYDROXY ACIDS
HYDROXY COMPOUNDS
INTESTINES
MAMMALS
NEUROREGULATORS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PHENOLS
POLYPHENOLS
RODENTS
SYMPATHOMIMETICS
THIOLS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals