Multiple myeloma among atomic bomb survivors in Hiroshima and Nagasaki, 1950-76: relationship to radiation dose absorbed by marrow
- Nagasaki Univ. School of Medicine, Japan
The relationship between atomic bomb exposure and the incidence of multiple myeloma has been examined in a fixed cohort of atomic bomb survivors and controls in the life-span study sample for Hiroshima and Nagasaki. From October 1950 to December 1976, 29 cases of multiple myeloma were confirmed in this sample. Our analysis shows that the standardized relative risk (RR) adjusted for city, sex, and age at the time of bombings (ATB) increased with marrow-absorbed radiation dose. The increased RR does not appear to differ between cities or sexes and is demonstrable only for those survivors whose age ATB was between 20 and 59 years. The estimaged risk in these individuals is approximately 0.48 cases/million person-years/rad for bone marrow total dose. This excess risk did not become apparent in individuals receiving 50 rad or more in marrow total dose until 20 years or more after exposure.
- OSTI ID:
- 6514310
- Journal Information:
- JNCI, J. Natl. Cancer Inst.; (United States), Vol. 69:2
- Country of Publication:
- United States
- Language:
- English
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A-BOMB SURVIVORS
DELAYED RADIATION EFFECTS
BONE MARROW CELLS
NEOPLASMS
RADIATION DOSES
HIROSHIMA
NAGASAKI
NUCLEAR EXPLOSIONS
NUCLEAR WEAPONS
ANIMAL CELLS
ASIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CONNECTIVE TISSUE CELLS
DISEASES
DOSES
EXPLOSIONS
HUMAN POPULATIONS
JAPAN
POPULATIONS
RADIATION EFFECTS
SOMATIC CELLS
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560151* - Radiation Effects on Animals- Man