Radiation absorbed dose estimates for oxygen-15 radiopharmaceuticals (H2( V)O, C VO, O VO) in newborn infants

Journal Article · Thu Dec 01 00:00:00 EST 1988 · J. Nucl. Med.; (United States)

OSTI ID:6514224

Powers, W J; Stabin, M; Howse, D; Eichling, J O; Herscovitch, P

In preparation for measurement of regional cerebral oxygen metabolism by positron emission tomography, radiation absorbed dose estimates for 19 internal organs, blood, and total body were calculated for newborn infants following bolus intravenous administration of H2( V)O and brief inhalation of C VO and O VO. Cumulated activity for each radiopharmaceutical was calculated from a compartmental model based on the known biologic behavior of the compound. Values for mean absorbed dose/unit cumulated activity (S) for internal organs and total body were based on a newborn phantom. S was separately calculated for blood. Total radiopharmaceutical absorbed dose estimates necessary to measure cerebral oxygen metabolism in a 3.51-kg infant based on 0.7 mCi/kg H2( V)O and 1 mCi/kg C VO and O VO were determined to be 1.6 rad to the lung (maximum organ dose), 0.28 rad to the marrow, 0.46 rad to the gonads, and 0.22 rad to total body. These values are similar to those for current clinical nuclear medicine procedures employing /sup 99m/Tc in newborn infants.

• Research Organization: Mallinckrodt Institute of Radiology, St. Louis, MO (USA)
• OSTI ID: 6514224
• Journal Information: J. Nucl. Med.; (United States), Vol. 29:12
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
61 RADIATION PROTECTION AND DOSIMETRY
62 RADIOLOGY AND NUCLEAR MEDICINE
INFANTS
RADIATION DOSES
OXYGEN
METABOLISM
BRAIN
CARBON MONOXIDE
OXYGEN 15
PHANTOMS
POSITRON COMPUTED TOMOGRAPHY
RADIOPHARMACEUTICALS
WATER
AGE GROUPS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBON COMPOUNDS
CARBON OXIDES
CENTRAL NERVOUS SYSTEM
CHALCOGENIDES
CHILDREN
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DOSES
DRUGS
ELEMENTS
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
HYDROGEN COMPOUNDS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MINUTES LIVING RADIOISOTOPES
MOCKUP
NERVOUS SYSTEM
NONMETALS
NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
OXYGEN ISOTOPES
RADIOISOTOPES
STRUCTURAL MODELS
TOMOGRAPHY
560161* - Radionuclide Effects
Kinetics
& Toxicology- Man
655003 - Medical Physics- Dosimetry
550601 - Medicine- Unsealed Radionuclides in Diagnostics