MRI effects on the teratogenicity of x-irradiation in the C57BL/6J mouse
Abstract
This investigation was undertaken in order to ascertain the combined effects of magnetic resonance imaging (MRI) fields and x-irradiation on the developing eye of the mouse strain C57B1/6J. Dams in groups of 15 were subjected to absorbed doses of 5, 15, and 30 cGy. Other dams (N = 15) were exposed to T2 spin-echo MRI fields under clinically realistic conditions following exposure to 30 cGy of x-irradiation. The developing eye was the biological end point studied. It was found that the 30-cGy dose resulted in teratogenic significance (p less than or equal to .05) for the C57B1/6J mouse. Groups exposed to both types of radiation fields demonstrated malformation levels similar to the 30-cGy irradiated animals with no additive or synergistic effects detected. The malformation rates and degree of statistical significance varied somewhat with unit of measurement, and analytical method. The results confirmed low level X-ray teratogenicity and suggested that the MRI techniques employed for this investigation did not enhance the teratogenicity of x-irradiation on eye malformations produced in the C57B1/6J mouse.
- Authors:
-
- Univ. of North Carolina, Chapel Hill (USA)
- Publication Date:
- OSTI Identifier:
- 6508914
- Resource Type:
- Journal Article
- Journal Name:
- Magnetic Resonance Imaging; (USA)
- Additional Journal Information:
- Journal Volume: 8:4; Journal ID: ISSN 0730-725X
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CONGENITAL MALFORMATIONS; RADIOINDUCTION; EYES; BIOLOGICAL RADIATION EFFECTS; X RADIATION; TERATOGENESIS; DOSE-RESPONSE RELATIONSHIPS; MICE; NMR IMAGING; RADIATION DOSES; SYNERGISM; ANIMALS; BIOLOGICAL EFFECTS; BODY; BODY AREAS; DIAGNOSTIC TECHNIQUES; DOSES; ELECTROMAGNETIC RADIATION; FACE; HEAD; IONIZING RADIATIONS; MALFORMATIONS; MAMMALS; ORGANS; PATHOLOGICAL CHANGES; RADIATION EFFECTS; RADIATIONS; RODENTS; SENSE ORGANS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
Citation Formats
Tyndall, D A. MRI effects on the teratogenicity of x-irradiation in the C57BL/6J mouse. United States: N. p., 1990.
Web. doi:10.1016/0730-725X(90)90051-3.
Tyndall, D A. MRI effects on the teratogenicity of x-irradiation in the C57BL/6J mouse. United States. https://doi.org/10.1016/0730-725X(90)90051-3
Tyndall, D A. 1990.
"MRI effects on the teratogenicity of x-irradiation in the C57BL/6J mouse". United States. https://doi.org/10.1016/0730-725X(90)90051-3.
@article{osti_6508914,
title = {MRI effects on the teratogenicity of x-irradiation in the C57BL/6J mouse},
author = {Tyndall, D A},
abstractNote = {This investigation was undertaken in order to ascertain the combined effects of magnetic resonance imaging (MRI) fields and x-irradiation on the developing eye of the mouse strain C57B1/6J. Dams in groups of 15 were subjected to absorbed doses of 5, 15, and 30 cGy. Other dams (N = 15) were exposed to T2 spin-echo MRI fields under clinically realistic conditions following exposure to 30 cGy of x-irradiation. The developing eye was the biological end point studied. It was found that the 30-cGy dose resulted in teratogenic significance (p less than or equal to .05) for the C57B1/6J mouse. Groups exposed to both types of radiation fields demonstrated malformation levels similar to the 30-cGy irradiated animals with no additive or synergistic effects detected. The malformation rates and degree of statistical significance varied somewhat with unit of measurement, and analytical method. The results confirmed low level X-ray teratogenicity and suggested that the MRI techniques employed for this investigation did not enhance the teratogenicity of x-irradiation on eye malformations produced in the C57B1/6J mouse.},
doi = {10.1016/0730-725X(90)90051-3},
url = {https://www.osti.gov/biblio/6508914},
journal = {Magnetic Resonance Imaging; (USA)},
issn = {0730-725X},
number = ,
volume = 8:4,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 1990},
month = {Mon Jan 01 00:00:00 EST 1990}
}