Brain damage from sup 125 I brachytherapy evaluated by MR imaging, a blood-brain barrier tracer, and light and electron microscopy in a rat model

Journal Article · Mon Oct 01 00:00:00 EDT 1990 · Journal of Neurosurgery; (USA)

DOI:https://doi.org/10.3171/jns.1990.73.4.0585· OSTI ID:6508859

Bernstein, M; Marotta, T; Stewart, P; Glen, J; Resch, L; Henkelman, M ^[1]

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1. Toronto Western Hospital, Ontario (Canada)

Changes in normal rat brain were studied acutely, and at 3, 6, 9, and 12 months following interstitial brachytherapy with high-activity {sup 125}I seeds. An 80-Gy radiation dose was administered to an area with a 5.5-mm radius. Effects were measured with magnetic resonance (MR) imaging (with and without gadolinium enhancement), leakage of horseradish peroxidase (HRP), electron microscopy, and light microscopy. Significant histological damage was seen at radiation doses above 295 Gy, and breakdown of the blood-brain barrier was observed only in tissue receiving a dose of 165 Gy or greater. Blood-brain barrier breakdown increased up to the 6-month time point, and thereafter appeared to stabilize or decrease. The area of blood-brain barrier disruption indicated by gadolinium-enhanced MR imaging was greater than that indicated by leakage of HRP.

• OSTI ID: 6508859
• Journal Information: Journal of Neurosurgery; (USA), Vol. 73:4; ISSN 0022-3085
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
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RADIOTHERAPY
SIDE EFFECTS
BLOOD-BRAIN BARRIER
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ENZYMES
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MAGNETIC RESONANCE
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560152* - Radiation Effects on Animals- Animals
550600 - Medicine