Ancient conserved regions in new gene sequences and the protein databases

Journal Article · Fri Mar 19 00:00:00 EST 1993 · Science (Washington, D.C.); (United States)

DOI:https://doi.org/10.1126/science.8456298· OSTI ID:6501879

Green, P; Hillier, L; Waterston, R ^[1]; Lipman, D; States, D; Claverie, J M ^[2]

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1. Washington Univ., St Louis, MO (United States)
2. National Institutes of Health, Bethesda, MD (United States)

Sets of new gene sequences from human, nematode, and yeast were compared with each other and with a set of Escherichia coli genes in order to detect ancient evolutionarily conserved regions (ACRs) in the encoded proteins. Nearly all of the ACRs so identified were found to be homologous to sequences in the protein databases. This suggests that currently known proteins may already include representatives of most ACRs and that new sequences not similar to any database sequence are unlikely to contain ACRs. Preliminary analyses indicate that moderately expressed genes may be more likely to contain ACRs than rarely expressed genes. It is estimated that there are fewer than 900 ACRs in all. 20 refs., 2 figs., 4 tabs.

• OSTI ID: 6501879
• Journal Information: Science (Washington, D.C.); (United States), Vol. 259:5102; ISSN 0036-8075
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
GENES
DNA SEQUENCING
PROTEINS
BIOLOGICAL EVOLUTION
ALDOLASES
CYCLASES
GENE REGULATION
GROWTH FACTORS
ISOMERASES
NEUROREGULATORS
OXIDOREDUCTASES
PHOSPHOTRANSFERASES
RIBOSOMES
RNA
SERINE PROTEINASES
AUTONOMIC NERVOUS SYSTEM AGENTS
CARBON-CARBON LYASES
CELL CONSTITUENTS
DRUGS
ENZYMES
HYDROLASES
LYASES
MITOGENS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PEPTIDE HYDROLASES
PHOSPHORUS-GROUP TRANSFERASES
STRUCTURAL CHEMICAL ANALYSIS
TRANSFERASES
550400* - Genetics