Effects of cyclophosphamide and irradiation singly and in combination upon SaI growth in A/J mice
The effects of various doses of cyclophosphamide and low-dose (15 rads) radiation upon the size of tumors caused by 10(4) Sarcoma I (SaI) cells was determined. In intact A/Jax (A/J) recipients, the effect of the two agents singly and in combination was found to be dependent especially upon the dosage of cyclophosphamide and the time of its administration in relation to tumor inoculation. In cell transfer experiments to adult thymectomized, lethally irradiated, bone-marrow-restored (ATxXBM) mice, the effects of cyclophosphamide and irradiation appeared to be either overlapping (low dosages of cyclophosphamide) or additive (dosages of cyclophosphamide greater than or equal to 50 mg/kg), suggesting that the two agents exert their influence in dissimilar fashion, perhaps by injuring different cell types with the same basic function. The most pronounced conjoint effects are seen when low dosages of cyclophosphamide are given 3 days after the adoptive transfer of spleen cells from mice pretreated with low-dose irradiation. The implications of this observation with respect to immunotherapy are discussed.
- Research Organization:
- Univ. of New Mexico School of Medicine, Albuquerque
- OSTI ID:
- 6499603
- Journal Information:
- Am. J. Pathol.; (United States), Vol. 2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
SARCOMAS
COMBINED THERAPY
CHEMOTHERAPY
DOSE-RESPONSE RELATIONSHIPS
EXPERIMENTAL NEOPLASMS
IMMUNITY
IMMUNOTHERAPY
LETHAL IRRADIATION
MICE
RADIOTHERAPY
SPLEEN
TRANSPLANTS
ANIMALS
BODY
DISEASES
IRRADIATION
MAMMALS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
RADIOLOGY
RODENTS
THERAPY
VERTEBRATES
550603* - Medicine- External Radiation in Therapy- (1980-)
550600 - Medicine
560152 - Radiation Effects on Animals- Animals