A multivariate linear regression model for predicting children's blood lead levels based on soil lead levels: A study at four Superfund sites
- Agency for Toxic Substances and Disease Registry, Atlanta, GA (United States). Div. of Health Studies
For the purpose of examining the association between blood lead levels and household-specific soil lead levels, the authors used a multivariate linear regression model to find a slope factor relating soil lead levels to blood lead levels. They used previously collected data from the Agency for Toxic Substances and Disease Registry's (ATSDR's) multisite lead and cadmium study. The data included in the blood lead measurements of 1,015 children aged 6--71 months, and corresponding household-specific environmental samples. The environmental samples included lead in soil, house dust, interior paint, and tap water. After adjusting for income, education or the parents, presence of a smoker in the household, sex, and dust lead, and using a double log transformation, they found a slope factor of 0.1388 with a 95% confidence interval of 0.09--0.19 for the dose-response relationship between the natural log of the soil lead level and the natural log of the blood lead level. The predicted blood lead level corresponding to a soil lead level of 500 mg/kg was 5.99 [micro]g/kg with a 95% prediction interval of 2.08--17.29. Predicted values and their corresponding prediction intervals varied by covariate level. The model shows that increased soil lead level is associated with elevated blood leads in children, but that predictions based on this regression model are subject to high levels of uncertainty and variability.
- OSTI ID:
- 6481679
- Journal Information:
- Environmental Research, Vol. 81:1; ISSN 0013-9351
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BLOOD
CHILDREN
DRINKING WATER
LEAD
MATHEMATICAL MODELS
MONITORING
MULTIVARIATE ANALYSIS
REGRESSION ANALYSIS
SOILS
US SUPERFUND
AGE GROUPS
BIOLOGICAL MATERIALS
BODY FLUIDS
ELEMENTS
HYDROGEN COMPOUNDS
LAWS
MATERIALS
MATHEMATICS
METALS
OXYGEN COMPOUNDS
POLLUTION LAWS
STATISTICS
WATER
540250* - Environment
Terrestrial- Site Resource & Use Studies- (1990-)
560300 - Chemicals Metabolism & Toxicology