Effect of thyrotrophin releasing hormone on opiate receptors of the rat brain
It has recently been shown that the hypothalamic thyrotropin releasing hormone (TRH) has the properties of a morphine antagonist, blocking its inhibitory action on respiration and, to a lesser degree, its analgesic action. This suggests that the antagonistic effects of TRH are mediated through its interaction with opiate receptors. The aim of this paper is to study this hypothesis experimentally. Tritium-labelled enkephalins in conjunction with scintillation spectroscopy were used to assess the receptor binding behavior. The results indicate the existence of interconnections between the opiate systems and TRH. Although it is too early to reach definite conclusions on the mechanisms of this mutual influence and its physiological significance it can be tentatively suggested that TRH abolishes the pharmacological effects of morphine by modulating the functional state of opiate reception.
- Research Organization:
- V.P. Serbskii All-Union Research Institute of General and Forensic Psychiatry, Moscow, USSR
- OSTI ID:
- 6478059
- Journal Information:
- Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Vol. 102:8; Other Information: Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny; 102: No. 8, 174-176(Aug 1986)
- Country of Publication:
- United States
- Language:
- English
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ENKEPHALINS
UPTAKE
MORPHINE
RECEPTORS
NERVE CELLS
RADIORECEPTOR ASSAY
TRH
BIOLOGICAL EFFECTS
BRAIN
INHIBITION
LABELLING
NARCOTICS
RATS
RESPIRATION
RESPONSE MODIFYING FACTORS
SCINTILLATION COUNTING
TRITIUM COMPOUNDS
ALKALOIDS
ANALGESICS
ANIMAL CELLS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BODY
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM DEPRESSANTS
COUNTING TECHNIQUES
DRUGS
ENDORPHINS
HORMONES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MEMBRANE PROTEINS
NERVOUS SYSTEM
NEUROREGULATORS
OPIUM
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
PEPTIDES
POLYPEPTIDES
PROTEINS
RODENTS
SOMATIC CELLS
TRACER TECHNIQUES
VERTEBRATES
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