Subcutaneous administration of carrier erythrocytes: slow release of entrapped agent

Journal Article · Mon Aug 01 00:00:00 EDT 1988 · Biotechnol. Appl. Biochem.; (United States)

OSTI ID:6470118

DeLoach, J R; Corrier, D E

Carrier erythrocytes administered subcutaneously in mice release encapsulated molecules at the injection site and through cells that escape the injection site. One day postinjection, the efflux of encapsulated (/sup 14/C)sucrose, (/sup 3/H)inulin, and /sup 51/Cr-hemoglobin from the injection site was 45, 55, and 65%, respectively. Intact carrier erythrocytes escaped the injection site and entered the blood circulation carrying with them the encapsulated molecules. Most of the encapsulated (/sup 3/H)inulin that reached whole blood circulated within erythrocytes. Small but measurable numbers of encapsulated molecules were trapped within lymph nodes. Subcutaneous injection of carrier erythrocytes may allow for limited extravascular tissue targeting of drugs.

• Research Organization: United States Department of Agriculture, College Station, TX (USA)
• OSTI ID: 6470118
• Journal Information: Biotechnol. Appl. Biochem.; (United States), Vol. 10:4
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ERYTHROCYTES
SUBCUTANEOUS INJECTION
HEMOGLOBIN
TISSUE DISTRIBUTION
INULIN
SACCHAROSE
BLOOD CIRCULATION
CARBON 14 COMPOUNDS
CHROMIUM 51
MICE
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOHYDRATES
CARBOXYLIC ACIDS
CHROMIUM ISOTOPES
DISACCHARIDES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GLOBIN
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MATERIALS
NUCLEI
OLIGOSACCHARIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PIGMENTS
POLYSACCHARIDES
PORPHYRINS
PROTEINS
RADIOISOTOPES
RODENTS
SACCHARIDES
VERTEBRATES
550201* - Biochemistry- Tracer Techniques