Enhanced cis-platinum ototoxicity in children with brain tumours who have received simultaneous or prior cranial irradiation

Journal Article · Sun Jan 01 00:00:00 EST 1989 · Med. Pediatr. Oncol.; (United States)

DOI:https://doi.org/10.1002/mpo.2950170110· OSTI ID:6469306

Walker, D A; Pillow, J; Waters, K D; Keir, E

We report on four children who received cis-platinum simultaneously with, or in one case 10 months after, cranial irradiation and experienced exaggerated ototoxicity affecting all audible frequencies. The hearing loss was severe, affecting the critical areas for speech perception, and necessitated the provision of bilateral hearing aids. The audiograms of these patients are shown and compared to those of four children who had received cis-platinum as part of their treatment for neuroblastoma but without cranial irradiation. The precipitation of the exaggerated hearing loss with the administration of cis-platinum in one patient 10 months after finishing cranial irradiation suggests that care should be taken in the timing of cis-platinum administration in relation to concurrent or previous cranial irradiation.

• Research Organization: Royal Children's Hospital, Victoria (Australia)
• OSTI ID: 6469306
• Journal Information: Med. Pediatr. Oncol.; (United States), Vol. 17:1
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AUDITORY ORGANS
SENSITIVITY
BRAIN
NEOPLASMS
COMBINED THERAPY
PLATINUM
TOXICITY
CHILDREN
RADIOTHERAPY
AGE GROUPS
BODY
CENTRAL NERVOUS SYSTEM
DISEASES
ELEMENTS
MEDICINE
METALS
NERVOUS SYSTEM
NUCLEAR MEDICINE
ORGANS
PLATINUM METALS
RADIOLOGY
SENSE ORGANS
THERAPY
TRANSITION ELEMENTS
550600* - Medicine
560151 - Radiation Effects on Animals- Man