Pulsatile hyperglucagonemia fails to increase hepatic glucose production in normal man

Journal Article · Thu Jan 01 00:00:00 EST 1987 · Am. J. Physiol.; (United States)

OSTI ID:6468816

Paolisso, G; Scheen, A J; Luyckx, A S; Lefebvre, P J

To study the metabolic effects of pulsatile glucagon administration, six male volunteers were submitted to a 260-min glucose-controlled glucose intravenous infusion using the Biostator. The endogenous secretion of the pancreatic hormones was inhibited by somatostatin, basal insulin secretion was replaced by a continuous insulin infusion, and glucagon was infused intravenously in two conditions at random: either continuously or intermittently. Blood glucose levels and glucose infusion rate were monitored continuously by the Biostator, and classical methodology using a D-(3-/sup 3/H)glucose infusion allowed the authors to study glucose turnover. While basal plasma glucagon levels were similar in both conditions, they plateaued at 189 +/- 38 pg ml/sup -1/ during continuous infusion and varied between 95 and 501 pg x ml/sup -1/ during pulsatile infusion. When compared with continuous administration, pulsatile glucagon infusion 1) initially induced a similar increase in endogenous (hepatic) glucose production and blood glucose, 2) did not prevent the so-called evanescent effect of glucagon on blood glucose, and 3) after 3 h tended to reduce rather than increase hepatic glucose production. In conclusion, in vivo pulsatile hyperglucanemia in normal man fails to increase hepatic glucose production.

• Research Organization: Univ. of Liege, Belgium
• OSTI ID: 6468816
• Journal Information: Am. J. Physiol.; (United States), Vol. 252:1
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
GLUCOSE
BLOOD CHEMISTRY
LIVER
BIOCHEMICAL REACTION KINETICS
TRITIUM COMPOUNDS
MAN
METABOLIC DISEASES
ALDEHYDES
ANIMALS
BODY
CARBOHYDRATES
DIGESTIVE SYSTEM
DISEASES
GLANDS
HEXOSES
KINETICS
LABELLED COMPOUNDS
MAMMALS
MONOSACCHARIDES
ORGANIC COMPOUNDS
ORGANS
PRIMATES
REACTION KINETICS
SACCHARIDES
VERTEBRATES
551001* - Physiological Systems- Tracer Techniques