Appearance of circulating and tissue /sup 14/C-lipids after oral /sup 14/C-tripalmitate administration in the late pregnant rat
Studies were performed to determine whether and/or how dietary lipids participate in maternal hypertriglyceridemia during late gestation in the rat. After oral administration of glycerol-tri(1-14C)-palmitate, total radioactivity in plasma increased more rapidly in 20-day pregnant rats than in either 19-day pregnant rats or virgin controls. At the peak of plasma radioactivity, four hours after the tracer was administered, most of the plasma label corresponded to 14C-lipids in triglyceride-rich lipoproteins (d less than 1.006), and when expressed per micromol of triglyceride, values were higher in pregnant than in virgin rats. The difference was less after 24 hours, although at this time the level of 14C-lipids in d less than 1.006 lipoproteins was still higher in 20-day pregnant rats than in virgins. Tissue 14C-lipids, as expressed per gram of fresh weight, were similar in pregnant and virgin rats, but the values in mammary glands were much higher in the former group. Estimated recovery of administered radioactivity four hours after tracer in total white adipose tissue, mammary glands, and plasma lipids was higher in pregnant than in virgin rats. No difference was found between 20-day pregnant and virgin rats either in the label retained in the gastrointestinal tract or in that exhaled as 14C-CO2 during the first four hours following oral administration of 14C-tripalmitate. These findings plus the known maternal hyperphagia, indicate that in the rat at late pregnancy triglyceride intestinal absorption is unchanged or even enhanced and that dietary lipids actively contribute to both maternal hypertriglyceridemia and lipid uptake by the mammary gland.
- Research Organization:
- Universidad de Barcelona (Spain)
- OSTI ID:
- 6467433
- Journal Information:
- Metab., Clin. Exp.; (United States), Vol. 38:2
- Country of Publication:
- United States
- Language:
- English
Similar Records
Global gene expression and morphological alterations in the mammary gland after gestational exposure to bisphenol A, genistein and indole-3-carbinol in female Sprague-Dawley offspring
Susceptibility of fetal, virgin, pregnant and lactating rats for the induction of mammary tumors by gamma rays
Related Subjects
LIPIDS
BIOCHEMICAL REACTION KINETICS
METABOLIC DISEASES
PATHOGENESIS
TRIGLYCERIDES
INTESTINAL ABSORPTION
ADIPOSE TISSUE
CARBON 14 COMPOUNDS
HEXADECANOIC ACID
ISOTOPE DILUTION
MAMMARY GLANDS
ORAL ADMINISTRATION
PREGNANCY
RATS
ABSORPTION
ANIMAL TISSUES
ANIMALS
BODY
CARBOXYLIC ACIDS
CONNECTIVE TISSUE
DISEASES
ESTERS
GLANDS
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MAMMALS
MONOCARBOXYLIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
REACTION KINETICS
RODENTS
TISSUES
TRACER TECHNIQUES
UPTAKE
VERTEBRATES
550901* - Pathology- Tracer Techniques