Changes in delayed hypersensitivity reaction in mice exposed to O/sub 3/

Journal Article · Mon Jun 01 00:00:00 EDT 1987 · Environ. Res.; (United States)

OSTI ID:6465355

Fujimaki, H; Shiraishi, F; Ashikawa, T; Murakami, M

BALB/c mice were continuously exposed to 0.8 ppm O/sub 3/ for 1, 3, 7, and 14 days. Ozone exposure suppressed the delayed hypersensitivity (DH) reaction to sheep red blood cells (SRBC). The maximum effect was seen after 7 days of exposure. To estimate the suppression of the DH reaction by O/sub 3/ exposure, the numbers of lymphocytes in thymus and blood of exposed mice were compared with those of control mice. A decrease in the numbers of lymphocytes in both thymus and blood was observed in O/sub 3/-exposed mice. The percentage of T and B lymphocytes in blood of exposed mice was the same as that in blood of control mice. These results suggest that 0.8 ppm O/sub 3/ exposure affects the T lymphocytes required for DH reactions.

• Research Organization: National Institute for Environmental Studies, Ibaraki, Japan
• OSTI ID: 6465355
• Journal Information: Environ. Res.; (United States), Vol. 1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LYMPHOCYTES
CELL PROLIFERATION
MICE
IMMUNE REACTIONS
OZONE
BIOLOGICAL EFFECTS
ERYTHROCYTES
SENSITIVITY
SHEEP
THYMUS
ANIMAL CELLS
ANIMALS
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BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DOMESTIC ANIMALS
LEUKOCYTES
LYMPHATIC SYSTEM
MAMMALS
MATERIALS
ORGANS
RODENTS
RUMINANTS
SOMATIC CELLS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology