Test of carcinogenicity in mouse skin: Methylenedianiline,. gamma. glycidyloxytrimethyloxysilane,. gamma. aminopropyltriethoxysilane and a mixture of m-phenylenediamine, methylenedianiline, and diglycidylether of bisphenol-A

Technical Report · Mon Jun 01 00:00:00 EDT 1987

DOI:https://doi.org/10.2172/6450404· OSTI ID:6450404

Holland, J. M.; Smith, L. H.; Frome, E.; Whitaker, M. J.; Gipson, L. C.; Fry, R. J.M.

Application of graded concentrations of four test substances in acetone to the skin of C3H mice five times a week resulted in the following: ..gamma..aminopropyltriethoxysilane at concentration of 100 and 50 wt/vol % was a severe and mild skin irritant in female C3Hf/Bd respectively and in males a mild skin irritant. Methylenedianiline at a concentration of 10 wt/vol % in methanol killed 4/9 females and 1/9 males. When acetone was the solvent 3/10 females and 3/10 males died within 2 weeks. No mortality or skin damage occurred with ..gamma..glycidyloxytrimethyloxysilane or the mixture of m-phenylenediamine, methylenedianiline and diglycidylether of bisphenol A (MDA). A study of the effects of a two-year, three times a week, topical application of the four test materials revealed no significant increase in skin tumors. The incidence of liver tumors appeared to be increased by exposure to methylenedianiline and with the mixture (MDA). Significant and dose-dependent increases in mortality were found in male mice with MDA and increased mortality at the highest dose (10.8 mg/week) in females. In the case of methylenedianiline excess mortality was found in both sexes. The precise cause of excess mortality from dermal absorption of the materials applied over a two-year period was not established. 5 refs., 12 figs., 12 tabs.

• Research Organization: Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
• DOE Contract Number: AC05-84OR21400
• OSTI ID: 6450404
• Report Number(s): ORNL/TM-10472; ON: DE87010421
• Resource Relation: Other Information: Portions of this document are illegible in microfiche products
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
CARCINOGENESIS
TOXICITY
AROMATICS
SILANES
ACUTE EXPOSURE
ANILINE
CHRONIC EXPOSURE
MICE
MORTALITY
SKIN ABSORPTION
ABSORPTION
ANIMALS
HYDRIDES
HYDROGEN COMPOUNDS
MAMMALS
ORGANIC COMPOUNDS
ORGANIC SILICON COMPOUNDS
PATHOGENESIS
RODENTS
SILICON COMPOUNDS
UPTAKE
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology