Identification of mutagens by frequency analysis of micronuclear normochromic erythrocytes
Analysis of the frequency of polychromatophilic erythrocytes with micronuclei in mammalian bone marrow is a rapid and simple test used at the stage of detection of potential mutagens and carcinogens. Reports have recently been published that normochromic erythrocytes with micronuclei may accumulate in the peripheral blood of mice exposed repeatedly to chemical mutagens. The authors of these reports recommend that this modified micronuclear test be used for the intravital detection of mutagens. To assess the potential of this method for investigating the effects of mutagenic and carcinogenic pollutants occurring in drinking water, the authors of this paper compared the frequency of mature normochromic erythrocytes and young polychromatophilic erythrocytes with micronuclei in the peripheral blood as well as the frequency of chromosomal aberrations in the bone marrow cells of mice who were given cyclophosphamide, a model mutagen, with their drinking water.
- Research Organization:
- A.N. Sysin Research Institute of General and Community Hygiene, Moscow, USSR
- OSTI ID:
- 6450102
- Journal Information:
- Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Vol. 102:8; Other Information: Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny; 102: No. 8, 222-224(Aug 1986)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
BONE MARROW CELLS
CHROMOSOMAL ABERRATIONS
MUTAGENESIS
ENDOXAN
DETECTION
GENETIC EFFECTS
ERYTHROCYTES
CELL NUCLEI
MUTAGENS
BIOASSAY
BIOLOGICAL ACCUMULATION
BIOLOGICAL MODELS
BLOOD
CARCINOGENS
CHROMOSOMES
CHRONIC INTAKE
DOSE-RESPONSE RELATIONSHIPS
DRINKING WATER
HEALTH HAZARDS
POLLUTANTS
WATER POLLUTION
ALKYLATING AGENTS
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD CELLS
BODY FLUIDS
CELL CONSTITUENTS
CONNECTIVE TISSUE CELLS
DRUGS
HAZARDS
HYDROGEN COMPOUNDS
IMMUNOSUPPRESSIVE DRUGS
INTAKE
MATERIALS
MUTATIONS
OXYGEN COMPOUNDS
POLLUTION
SOMATIC CELLS
WATER
560300* - Chemicals Metabolism & Toxicology
550400 - Genetics
550300 - Cytology