Thoracic and elective brain irradiation with concomitant or delayed multiagent chemotherapy in the treatment of localized small cell carcinoma of the lung: a randomized prospective study by the Southeastern Cancer Study Group. [X-ray]

Journal Article · Fri May 15 00:00:00 EDT 1981 · Cancer; (United States)

DOI:https://doi.org/10.1002/1097-0142(19810515)47:10<2407::AID-CNCR2820471015>3.0.CO;2-R· OSTI ID:6449027

Perez, C A ^[1]; Krauss, S; Bartolucci, A A; Durant, J R; Lowenbraun, S; Salter, M M; Storaasli, J; Kellermeyer, R; Comas, F

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1. Washington Univ., St. Louis, MO

A prospective randomized study was carried out to compare the effectiveness of concomitant or delayed multiagent chemotherapy combined with irradiation to the primary tumor and regional lymph nodes and to the brain in a group of 70 patients with histologically proven small cell undifferentiated carcinoma of the lung. Complete and partial response in both groups was comparable, and the overall survival was comparable. However, relapse-free survival was significantly higher in patients receiving concomitant chemotherapy and irradiation in comparison with the radiotherapy alone group. Disease-free survival was higher in the concomitant chemotherapy-radiotherapy patients, although survival was not significantly modified, probably because of suboptimal chemotherapy. The incidence of distant metastasis was slightly lower in the chemotherapy groups. Brain metastases were noted in 7% of the patients in both groups. Increased intrathoracic recurrences were noted in patients with lower doses of irradiation. The study emphasizes the need for intensive chemotherapy and adequate radiation therapy to improve survival of patients with small cell undifferentiated carcinoma of the lung.

• OSTI ID: 6449027
• Journal Information: Cancer; (United States), Vol. 47:10
• Country of Publication: United States
• Language: English

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