Two new rodent models for actinide toxicity studies. [/sup 237/Pu, /sup 241/Am]
Abstract
Two small rodent species, the grasshopper mouse (Onychomys leucogaster) and the deer mouse (Peromyscus maniculatus), have tenacious and high retention in the liver and skeleton of plutonium and americium following intraperitoneal injection of Pu and Am in citrate solution. Liver retention of Pu and Am in the grasshopper mouse is higher than liver retention in the deer mouse. Both of these rodents are relatively long-lived, breed well in captivity, and adapt suitably to laboratory conditions. It is suggested that these two species of mice, in which plutonium retention is high and prolonged in both the skeleton and liver, as it is in man, may be useful animal models for actinide toxicity studies.
- Authors:
- Publication Date:
- Research Org.:
- Univ. of Utah, Salt Lake City
- OSTI Identifier:
- 6442262
- DOE Contract Number:
- AC02-76EV00119
- Resource Type:
- Journal Article
- Journal Name:
- Radiat. Res.; (United States)
- Additional Journal Information:
- Journal Volume: 86:1
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; AMERICIUM 241; RETENTION; LIVER; RADIONUCLIDE KINETICS; PLUTONIUM 237; BIOLOGICAL MODELS; SKELETON; CITRATES; MICE; ACTINIDE ISOTOPES; ACTINIDE NUCLEI; ALPHA DECAY RADIOISOTOPES; AMERICIUM ISOTOPES; ANIMALS; BETA DECAY RADIOISOTOPES; BODY; CARBOXYLIC ACID SALTS; DAYS LIVING RADIOISOTOPES; DIGESTIVE SYSTEM; ELECTRON CAPTURE RADIOISOTOPES; EVEN-ODD NUCLEI; GLANDS; HEAVY NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; NUCLEI; ODD-EVEN NUCLEI; ORGANS; PLUTONIUM ISOTOPES; RADIOISOTOPES; RODENTS; SECONDS LIVING RADIOISOTOPES; VERTEBRATES; YEARS LIVING RADIOISOTOPES; 560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)
Citation Formats
Taylor, G N, Jones, C W, Gardner, P A, Lloyd, R D, Mays, C W, and Charrier, K E. Two new rodent models for actinide toxicity studies. [/sup 237/Pu, /sup 241/Am]. United States: N. p., 1981.
Web. doi:10.2307/3575603.
Taylor, G N, Jones, C W, Gardner, P A, Lloyd, R D, Mays, C W, & Charrier, K E. Two new rodent models for actinide toxicity studies. [/sup 237/Pu, /sup 241/Am]. United States. https://doi.org/10.2307/3575603
Taylor, G N, Jones, C W, Gardner, P A, Lloyd, R D, Mays, C W, and Charrier, K E. 1981.
"Two new rodent models for actinide toxicity studies. [/sup 237/Pu, /sup 241/Am]". United States. https://doi.org/10.2307/3575603.
@article{osti_6442262,
title = {Two new rodent models for actinide toxicity studies. [/sup 237/Pu, /sup 241/Am]},
author = {Taylor, G N and Jones, C W and Gardner, P A and Lloyd, R D and Mays, C W and Charrier, K E},
abstractNote = {Two small rodent species, the grasshopper mouse (Onychomys leucogaster) and the deer mouse (Peromyscus maniculatus), have tenacious and high retention in the liver and skeleton of plutonium and americium following intraperitoneal injection of Pu and Am in citrate solution. Liver retention of Pu and Am in the grasshopper mouse is higher than liver retention in the deer mouse. Both of these rodents are relatively long-lived, breed well in captivity, and adapt suitably to laboratory conditions. It is suggested that these two species of mice, in which plutonium retention is high and prolonged in both the skeleton and liver, as it is in man, may be useful animal models for actinide toxicity studies.},
doi = {10.2307/3575603},
url = {https://www.osti.gov/biblio/6442262},
journal = {Radiat. Res.; (United States)},
number = ,
volume = 86:1,
place = {United States},
year = {Wed Apr 01 00:00:00 EST 1981},
month = {Wed Apr 01 00:00:00 EST 1981}
}
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