Activation of Trp-P-1 and Trp-P-2 in vitro and in vivo

Journal Article · Fri Jan 01 00:00:00 EST 1982 · Nutr. Cancer; (United States)

OSTI ID:6428510

Dolara, P; Caderni, G; Benetti, D

Isolated perfused livers were not able to activate the promutagens Trp-P-1 and Trp-P-2 to their genotoxic metabolites. On the contrary, inherently active mutagenic compounds were detected in the bile of living rats to which Trp-P-1 and Trp-P-2 had been administered intravenously. The excretion of active mutagens through the bile may explain the tumorigenic effect that these compounds exert on the liver during chronic feeding experiments.

• Research Organization: Institute of Pharmacology and Toxicology of the University of Florence, Italy
• OSTI ID: 6428510
• Journal Information: Nutr. Cancer; (United States), Vol. 3:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
LIVER
SENSITIVITY
MUTAGENS
BIOLOGICAL EFFECTS
METABOLISM
RATS
BILE
BIOLOGICAL PATHWAYS
CARCINOGENESIS
COMPARATIVE EVALUATIONS
IN VITRO
IN VIVO
METABOLITES
ANIMALS
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
DIGESTIVE SYSTEM
GLANDS
MAMMALS
MATERIALS
ORGANS
PATHOGENESIS
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
550200 - Biochemistry
550400 - Genetics