Modifiers of radiation action on DNA screened by analytical ultracentrifugation
Journal Article
·
· Radiat. Res.; (United States)
The effect of daunomycin, chromomycin A/sub 3/, anthramycin, cis-dichlorodiammineplatinum(II) (cisplatin), mitomycin C, and chloroquine on the frequency of radioninduced strand breaks in X-irradiated aqueous solutions of DNA was studied primarily by analytical ultracentrifugation using the sedimentation velocity method. The results show a potent radiosensitizing effect for daunomycin and chromomycin, a protective action for chloroquine and mitomycin, and a nonmodifying effect for anthramycin. Cisplatin forms a highly aggregated complex with DNA which prevents this kind of study.
- Research Organization:
- Instituto de Quimica Fisica ''Rocasolano,'' CSIC, Madrid, Spain
- OSTI ID:
- 6426338
- Journal Information:
- Radiat. Res.; (United States), Vol. 92:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTIBIOTICS
RADIOSENSITIVITY EFFECTS
DNA
BIOLOGICAL RADIATION EFFECTS
PLATINUM
STRAND BREAKS
RADIOINDUCTION
AQUEOUS SOLUTIONS
DOSE-RESPONSE RELATIONSHIPS
MITOMYCIN
ULTRACENTRIFUGATION
X RADIATION
ANTI-INFECTIVE AGENTS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
BIOLOGICAL EFFECTS
CENTRIFUGATION
DISPERSIONS
DRUGS
ELECTROMAGNETIC RADIATION
ELEMENTS
IONIZING RADIATIONS
METALS
MIXTURES
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PLATINUM METALS
RADIATION EFFECTS
RADIATIONS
SEPARATION PROCESSES
SOLUTIONS
TRANSITION ELEMENTS
560111* - Radiation Effects on Biochemicals- In Vitro- (-1987)
ANTIBIOTICS
RADIOSENSITIVITY EFFECTS
DNA
BIOLOGICAL RADIATION EFFECTS
PLATINUM
STRAND BREAKS
RADIOINDUCTION
AQUEOUS SOLUTIONS
DOSE-RESPONSE RELATIONSHIPS
MITOMYCIN
ULTRACENTRIFUGATION
X RADIATION
ANTI-INFECTIVE AGENTS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
BIOLOGICAL EFFECTS
CENTRIFUGATION
DISPERSIONS
DRUGS
ELECTROMAGNETIC RADIATION
ELEMENTS
IONIZING RADIATIONS
METALS
MIXTURES
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PLATINUM METALS
RADIATION EFFECTS
RADIATIONS
SEPARATION PROCESSES
SOLUTIONS
TRANSITION ELEMENTS
560111* - Radiation Effects on Biochemicals- In Vitro- (-1987)