The response of kidney to ionizing radiation combined with hyperthermia induced by ultrasound

Journal Article · Mon Nov 01 00:00:00 EST 1982 · Radiology; (United States)

DOI:https://doi.org/10.1148/radiology.145.2.7134461· OSTI ID:6425918

Baker, D G; Sager, H T; Elkon, D; Constable, W; Rinehart, L; Wills, M; Savory, J; Lacher, D

Mouse kidneys were made hyperthermic (42.5/sup 0/C for 30 min) one hour before, during, or one hour after local irradiation to determine the effect of hyperthermia on radiation damage. An ultrasound beam was used to induce hyperthermia. The urinary concentrations of total protein and albumin were used as criteria of kidney injury. Hyperthermia alone did not induce proteinuria. Radiation alone produced proteinuria that was not correlated with dose. Hyperthermia induced during or after irradiation resulted in a thermal enhancement factor of 1.29+/-.33. Hyperthermia induced one hour before irradiation resulted in a thermal enhancement factor of 0.88+/-.05, indicating a radioprotective effect. To the authors' knowledge, this is the first time such an effect has been shown.

• Research Organization: Univ. of Virginia Hospital, Charlottesville
• OSTI ID: 6425918
• Journal Information: Radiology; (United States), Vol. 145:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALBUMINS
BIOLOGICAL RADIATION EFFECTS
HYPERTHERMIA
RADIOSENSITIVITY EFFECTS
PROTEINS
KIDNEYS
MICE
ULTRASONOGRAPHY
X RADIATION
ANIMALS
BIOLOGICAL EFFECTS
BODY
BODY TEMPERATURE
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
MAMMALS
ORGANIC COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIATIONS
RODENTS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals
560205 - Thermal Effects- Vertebrates- (-1987)