Impromidine-induced changes in the permeability of the blood-brain barrier of normotensive and spontaneously hypertensive rats

Journal Article · Wed Aug 01 00:00:00 EDT 1990 · Research Communications in Chemical Pathology and Pharmacology; (USA)

OSTI ID:6420391

Boertje, S B; Le Beau, D; Ward, S ^[1]

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1. Southern Univ. at New Orleans, LA (USA)

Previous studies suggested histamine receptors mediate changes in the cerebrovascular permeability of rats. To test this, we investigated the effects of impromidine, a specific agonist at the histamine H2-receptor, on blood pressure and permeability of the blood-brain barrier (BBB). Impromidine produced dose-dependent hypotension in Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats. Two higher doses of impromidine increased BBB permeability to 99mTc-sodium pertechnetate in WKY rats; however, two lower doses decreased permeability in SHR rats. All doses of impromidine increased cerebrovascular permeability to 131I-labeled serum albumin in both species. Doses of the drug were 100 times greater than those required to produce similar alterations using histamine.

• OSTI ID: 6420391
• Journal Information: Research Communications in Chemical Pathology and Pharmacology; (USA), Vol. 69:2; ISSN 0034-5164
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
BLOOD-BRAIN BARRIER
PERMEABILITY
HISTAMINE
RECEPTORS
BIOCHEMICAL REACTION KINETICS
ALBUMINS
BLOOD PRESSURE
DOSE-RESPONSE RELATIONSHIPS
IODINE 131
ISOMERIC NUCLEI
PERTECHNETATES
RATS
SODIUM COMPOUNDS
TECHNETIUM 99
TRACER TECHNIQUES
ALKALI METAL COMPOUNDS
AMINES
ANIMALS
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
DAYS LIVING RADIOISOTOPES
HETEROCYCLIC COMPOUNDS
HOURS LIVING RADIOISOTOPES
IMIDAZOLES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
MAMMALS
MEMBRANE PROTEINS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXYGEN COMPOUNDS
PROTEINS
RADIOISOTOPES
REACTION KINETICS
REFRACTORY METAL COMPOUNDS
RODENTS
TECHNETIUM COMPOUNDS
TECHNETIUM ISOTOPES
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
550901* - Pathology- Tracer Techniques