Ozone inhalation effects in females varying widely in lung size: Comparison with males

Journal Article · Sun Jul 01 00:00:00 EDT 1990 · Journal of Applied Physiology (1985); (USA)

OSTI ID:6418354

Messineo, T D; Adams, W C ^[1]

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1. Univ. of California, Davis (USA)

It has been suggested that lung size accounts for observed gender differences in responsiveness to the same total inhaled dose of O3. To test the hypothesis that lung size is a determinant of magnitude of response within a gender, two groups of 14 healthy young adult females differing significantly in forced vital capacity (FVC; i.e., small-lung group mean = 3.74 liters (range 3.2-4.0) and large-lung group mean = 5.11 liters (range 4.5-6.2)) were exposed for 1 h to filtered air (FA) and to 0.18 and 0.30 ppm O3. On each occasion, subjects exercised continuously on a cycle ergometer at a work rate that elicited a mean minute ventilation of approximately 47 l/min. For the small-lung group (mean total lung capacity (TLC) = 4.52 liters) exercise O2 uptake was 67% of maximal O2 uptake (VO2max), and that for the large-lung group (TLC 6.37 liters) was 61% of VO2max. Statistical analysis revealed significant decrements for both groups in FVC, forced expiratory volume in 1 s (FEV1.0), and forced expiratory flow rate in the middle half of FVC on exposure to 0.18 and 0.30 ppm O3. Exercise respiratory frequency increased, and tidal volume decreased significantly in both groups in response to 0.18 and 0.30 ppm O3 exposure. On exposure to 0.30 ppm O3, the number of individual subjective symptoms reported and their severity were significantly greater for both groups than those reported for the FA and 0.18 ppm O3 exposures. Both groups evidenced similar percent changes in pulmonary function and exercise ventilation response, and in subjective symptom response.

• OSTI ID: 6418354
• Journal Information: Journal of Applied Physiology (1985); (USA), Vol. 69:1; ISSN 8750-7587
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LUNGS
SENSITIVITY
OZONE
BIOLOGICAL EFFECTS
COMPARATIVE EVALUATIONS
EXERCISE
FEMALES
FLOW RATE
INHALATION
MALES
MAN
SEX DEPENDENCE
SIZE
ANIMALS
BODY
INTAKE
MAMMALS
ORGANS
PRIMATES
RESPIRATORY SYSTEM
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology