Age dependence of the level of the enzymes involved in the protection against active oxygen species in the rat brain
Abstract
Levels of Cu, Zn superoxide dismutase (CuSOD), Mn superoxide dismutase (MnSOD), catalase, and glutathione peroxidase (GPx) were assessed in the rat brain cortex. The concentrations of Cu- and MnSOD were found to increase linearly with the logarithm of the age of the animal from 3 days before birth to 30 months, both in the whole cortex tissue and in its cytoplasmic fraction. Catalase and GPx levels showed different trends; in particular, GPx, which appears to play a key role in detoxification of hydrogen peroxide, after an initial fall increases steadily with age. The enhancement of the levels of SOD and GPx could be related to protection against an increased production of reactive oxygen species in the aging process.
- Authors:
- Publication Date:
- Research Org.:
- Univ. of Padova, Italy
- OSTI Identifier:
- 6417377
- Resource Type:
- Journal Article
- Journal Name:
- Proc. Soc. Exp. Biol. Med.; (United States)
- Additional Journal Information:
- Journal Volume: 185:2
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; HYDROGEN PEROXIDE; DETOXIFICATION; PEROXIDASES; ENZYME ACTIVITY; SUPEROXIDE DISMUTASE; AGE DEPENDENCE; AGING; BRAIN; COPPER; GLUTATHIONE; MANGANESE; RADICALS; RATS; ZINC; ANIMALS; BODY; CENTRAL NERVOUS SYSTEM; DRUGS; ELEMENTS; ENZYMES; HYDROGEN COMPOUNDS; MAMMALS; METALS; NERVOUS SYSTEM; ORGANIC COMPOUNDS; ORGANS; OXIDOREDUCTASES; OXYGEN COMPOUNDS; PEPTIDES; PEROXIDES; POLYPEPTIDES; PROTEINS; RADIOPROTECTIVE SUBSTANCES; RODENTS; TRANSITION ELEMENTS; VERTEBRATES; 550200* - Biochemistry; 560300 - Chemicals Metabolism & Toxicology
Citation Formats
Scarpa, M, Rigo, A, Viglino, P, Stevanato, R, Bracco, F, and Battistin, L. Age dependence of the level of the enzymes involved in the protection against active oxygen species in the rat brain. United States: N. p., 1987.
Web. doi:10.3181/00379727-185-42526.
Scarpa, M, Rigo, A, Viglino, P, Stevanato, R, Bracco, F, & Battistin, L. Age dependence of the level of the enzymes involved in the protection against active oxygen species in the rat brain. United States. https://doi.org/10.3181/00379727-185-42526
Scarpa, M, Rigo, A, Viglino, P, Stevanato, R, Bracco, F, and Battistin, L. 1987.
"Age dependence of the level of the enzymes involved in the protection against active oxygen species in the rat brain". United States. https://doi.org/10.3181/00379727-185-42526.
@article{osti_6417377,
title = {Age dependence of the level of the enzymes involved in the protection against active oxygen species in the rat brain},
author = {Scarpa, M and Rigo, A and Viglino, P and Stevanato, R and Bracco, F and Battistin, L},
abstractNote = {Levels of Cu, Zn superoxide dismutase (CuSOD), Mn superoxide dismutase (MnSOD), catalase, and glutathione peroxidase (GPx) were assessed in the rat brain cortex. The concentrations of Cu- and MnSOD were found to increase linearly with the logarithm of the age of the animal from 3 days before birth to 30 months, both in the whole cortex tissue and in its cytoplasmic fraction. Catalase and GPx levels showed different trends; in particular, GPx, which appears to play a key role in detoxification of hydrogen peroxide, after an initial fall increases steadily with age. The enhancement of the levels of SOD and GPx could be related to protection against an increased production of reactive oxygen species in the aging process.},
doi = {10.3181/00379727-185-42526},
url = {https://www.osti.gov/biblio/6417377},
journal = {Proc. Soc. Exp. Biol. Med.; (United States)},
number = ,
volume = 185:2,
place = {United States},
year = {Mon Jun 01 00:00:00 EDT 1987},
month = {Mon Jun 01 00:00:00 EDT 1987}
}
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