Vasoactive intestinal peptide may participate in the vasodilation of the dog hepatic artery
The possible direct action of vasoactive intestinal peptide (VIP) on dog hepatic arterial wall or on the noradrenergic innervation of the artery was investigated in vitro. In addition, VIP-containing nerve fibers and terminals were located in the wall of the artery with immunochemical staining. Direct evidence showed that VIP did not affect the release of (TH)norepinephrine but reduced the response of the isolated hepatic artery to electrical field stimulation and exogenous norepinephrine. This suggest that the effect of VIP is postjunctional on the smooth muscle of the artery. VIP-containing nerve fibers and varicosities were observed in the adventitial and medial layer of the arterial wall. These findings strongly support the hypothesis that vasoactive intestinal peptide is a physiological mediator of vasodilation in the hepatic artery.
- Research Organization:
- Hungarian Academy of Sciences, Budapest
- OSTI ID:
- 6415800
- Journal Information:
- Am. J. Physiol.; (United States), Vol. 251:2
- Country of Publication:
- United States
- Language:
- English
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NORADRENALINE
SECRETION
TRITIUM COMPOUNDS
VASODILATORS
BIOCHEMISTRY
ARTERIES
CYTOCHEMISTRY
DOGS
GASTROINTESTINAL TRACT
LIVER
NERVES
PEPTIDES
SCINTILLATION COUNTING
VASODILATION
ADRENAL HORMONES
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BLOOD VESSELS
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR SYSTEM
CHEMISTRY
COUNTING TECHNIQUES
DIGESTIVE SYSTEM
DRUGS
GLANDS
HORMONES
LABELLED COMPOUNDS
MAMMALS
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANS
PROTEINS
STEROID HORMONES
SYMPATHOMIMETICS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques