Induction of sister chromatid exchanges by coal dust and tobacco snuff extracts in human peripheral lymphocytes
The organic solvent extracts of sub-bituminous coal dust and tobacco snuff, both together and separately, were tested for the induction of sister chromatid exchanges (SCEs) in human peripheral lymphocytes. The results indicate that these extracts induced SCEs, and that when tested together synergistically induced SCEs in two of three donors. Studies with the organic solvent extracts of all five ranks of coal indicate that the extracts of bituminous, lignite, and peat, but not anthracite, induced SCEs. Similar experiments conducted with water extracts, induced SCEs, and that anthracite was equivocal. To determine whether individuals differed in their SCE responses to coal dust extracts, lymphocytes from five donors were tested with organic solvent extracts of bituminous and sub-bituminous coal. An analysis of variance indicates that the SCE response was significantly influenced by the donor and each of the two coal extracts. The findings presented here suggest that coal dust, with or without tobacco snuff, may play a role in the elevated incidence of gastric cancer in coal miners. Because water extracts of some ranks of coal induced SCEs, there exists the possibility of adverse environmental effects due to coal leachates.
- Research Organization:
- National Institute for Occupational Safety and Health, Morgantown, WV
- OSTI ID:
- 6415339
- Journal Information:
- Environ. Mutagen.; (United States), Vol. 7:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
DUSTS
GENETIC EFFECTS
TOBACCO PRODUCTS
COAL
COAL EXTRACTS
EXPERIMENTAL DATA
INTESTINES
LYMPHOCYTES
MAN
NEOPLASMS
SISTER CHROMATID EXCHANGES
SOLVENT EXTRACTION
STOMACH
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARBONACEOUS MATERIALS
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
DATA
DIGESTIVE SYSTEM
DISEASES
ENERGY SOURCES
EXTRACTION
FOSSIL FUELS
FUELS
GASTROINTESTINAL TRACT
INFORMATION
LEUKOCYTES
MAMMALS
MATERIALS
MUTATIONS
NUMERICAL DATA
ORGANS
PRIMATES
SEPARATION PROCESSES
SOMATIC CELLS
VERTEBRATES
016000* - Coal
Lignite
& Peat- Health & Safety
560306 - Chemicals Metabolism & Toxicology- Man- (-1987)