Chromium and vanadium effects on glucose and lipid metabolism of guinea pigs and obese and diabetic mice
Severe chromium deficiency in experimental animals may contribute to insulin resistance, impaired glucose tolerance and elevated serum cholesterol concentration. Vanadium also has been reported to be a nutritionally important element for both chicks and rats, but its function and even its essentiality are still in question. Chromium absorption even from supplemented diets is poor, thus efforts were made to study the site of absorption of /sup 51/Cr from CrCl/sub 3/. /sup 51/Cr was found to move very rapidly through the GI tract and appears to flow with dietary and secreted water. It was not absorbed from the stomach. In a study with guinea pigs, vanadate supplementation appeared to affect cholesterol fraction. Chromium supplementation lowered serum triacylglycerol concentrations at the end of an 18-week study. Since the previous study and others have indicated a role for chromium and vanadium in lipid carbohydrate metabolism, experiments were designed to compare effects of chromium and vanadium supplements on related parameters.
- Research Organization:
- Texas Tech Univ., Lubbock (USA)
- OSTI ID:
- 6408083
- Resource Relation:
- Other Information: Thesis (Ph. D.)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
CHROMIUM
BIOLOGICAL EFFECTS
GLUCOSE
METABOLISM
LIPIDS
VANADIUM
CHOLESTEROL
CHROMIUM 51
DIABETES MELLITUS
GUINEA PIGS
MICE
NUTRITIONAL DEFICIENCY
TRACER TECHNIQUES
TRIGLYCERIDES
ALDEHYDES
ANIMALS
BETA DECAY RADIOISOTOPES
CARBOHYDRATES
CHROMIUM ISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
ENDOCRINE DISEASES
ESTERS
EVEN-ODD NUCLEI
HEXOSES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
METABOLIC DISEASES
METALS
MONOSACCHARIDES
NUCLEI
ORGANIC COMPOUNDS
RADIOISOTOPES
RODENTS
SACCHARIDES
STEROIDS
STEROLS
TRANSITION ELEMENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology
550501 - Metabolism- Tracer Techniques