Localization and treatment of familial malignant nonfunctional paraganglioma with iodine-131 MIBG: report of two cases

Journal Article · Wed Apr 01 00:00:00 EST 1987 · J. Nucl. Med.; (United States)

OSTI ID:6406385

Khafagi, F; Egerton-Vernon, J; van Doorn, T; Foster, W; McPhee, I B; Allison, R W

Two cases of familial, malignant, nonfunctional paraganglioma are reported. Uptake of iodine-131 metaiodobenzylguanidine ((/sup 131/I)MIBG) by the tumors and metastases was demonstrated. In the first case, with multicentric and locally invasive disease, (/sup 131/I)MIBG correctly localized a right carotid body paraganglioma which had been missed arteriographically. In the second case, with widespread, symptomatic metastatic disease, a therapeutic dose of (/sup 131/I)MIBG produced palliation of bone pain after the failure of radio- and chemotherapy. Uptake of (/sup 131/I)MIBG by paragangliomas does not correlate with catecholamine secretory activity. Iodine-131 MIBG should be considered as a therapeutic option in unresectable, malignant paragangliomas which take up this radiopharmaceutical.

• Research Organization: Royal Brisbane Hospital, Australia
• OSTI ID: 6406385
• Journal Information: J. Nucl. Med.; (United States), Vol. 4
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BRAIN
NEOPLASMS
IODINE 131
THERAPEUTIC USES
BIOLOGICAL LOCALIZATION
RADIOTHERAPY
METASTASES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CENTRAL NERVOUS SYSTEM
DAYS LIVING RADIOISOTOPES
DISEASES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MEDICINE
NERVOUS SYSTEM
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
RADIOLOGY
THERAPY
USES
550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)