In vitro genotoxicity of chlorinated drinking water processed from humus-rich surface water
Chlorination by-products of drinking waters are capable of inducing sister chromatid exchanges (SCE) and chromosome aberrations (CA) in vitro, in addition to their mutagenic activity in the Ames test. Finnish drinking waters, processed from humus-rich surface water using chlorine disinfection, have been found to be highly mutagenic in the Ames' test. The highest activities have been found in the acidic, non-volatile fraction of the water concentrates using tester strain TA100 without metabolic activation by S9mix. The mutagenicities have varied between 500 and 14,000 induced revertants per liter. These figures are one to two magnitudes higher than those reported elsewhere. The authors studied five Finnish drinking water samples for their potency to exert genotoxic effects, SCEs and CAs, in mammalian cells in vitro (human peripheral lymphocytes and Chinese hamster lung fibroblasts).
- Research Organization:
- National Public Health Institute, Kuopio (Finland)
- OSTI ID:
- 6396241
- Journal Information:
- Bull. Environ. Contam. Toxicol.; (United States), Vol. 41:5
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CHLORINATION
GENETIC EFFECTS
DRINKING WATER
MUTAGEN SCREENING
CHROMOSOMAL ABERRATIONS
FIBROBLASTS
FINLAND
LUNGS
LYMPHOCYTES
METABOLIC ACTIVATION
SISTER CHROMATID EXCHANGES
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CHEMICAL REACTIONS
CONNECTIVE TISSUE CELLS
EUROPE
HALOGENATION
HYDROGEN COMPOUNDS
LEUKOCYTES
MATERIALS
MUTATIONS
ORGANS
OXYGEN COMPOUNDS
RESPIRATORY SYSTEM
SCANDINAVIA
SCREENING
SOMATIC CELLS
WATER
WESTERN EUROPE
560300* - Chemicals Metabolism & Toxicology