Unsymmetrical alkyl aryl thiourae compounds for use as cerebral blood flow tracers. [Rats]
The synthesis and characterization of an homologous series of inert nonvolatile /sup 14/C-labeled unsymmetrical alkyl aryl thiourea compounds is described for their use as regional blood flow (rCBF) tracers employing autoradiographic procedures. In alert normocapnic rats the single-pass extraction values into brain for these thioureas were found ranging from 0.497 for 1-methyl-3-phenylthiourea to 0.730 for 1-butyl-3-phenylthiourea. The commonly used rCBF tracers (14C) antipyrine and (14C) iodoantipyrine had single-pass extraction values of 0.451 and 0.553, respectively. Since 1-butyl-3-phenylthiourea diffused most readily into rat brain it was chosen as a potentially valuable rCBF tracer. Employing 1-butyl-3-phenylthiourea to measure rCBF nd its empirically derived brain extraction values the following flow rates in normocapnic rats were found: 3.2 ml . g-1 . min-1 for cochlear nucleus: 3.0 for inferior colliculus; 2.5 for medical geniculate; 1.9 for pontine gray and hypothalamus; 1.7 for caudate and cerebral cortex; and 1.2 for cerebellar gray and 0.41 to 0.50 for white matter structures. It was concluded from these studies that 1-butyl-3-phenylthiourea is more advantageous than iodoantipyrine for measuring rCBF, especially in those areas that possess very rapid rates of flow.
- Research Organization:
- New York Univ., NY
- OSTI ID:
- 6396057
- Journal Information:
- Am. J. Physiol.; (United States), Vol. 238:6
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ANTIPYRINE
DIAGNOSTIC USES
BLOOD FLOW
TRACER TECHNIQUES
BRAIN
CARBON 14 COMPOUNDS
THIOUREA
ALKYLATION
AUTORADIOGRAPHY
BLOOD PLASMA
BLOOD-BRAIN BARRIER
COMPARATIVE EVALUATIONS
ERYTHROCYTES
EXTRACTION
RADIOPHARMACEUTICALS
RATS
SOLUBILITY
ANIMALS
ANTIPYRETICS
ANTITHYROID DRUGS
AZOLES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARBONIC ACID DERIVATIVES
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CHEMICAL REACTIONS
DRUGS
HETEROCYCLIC COMPOUNDS
HORMONE ANTAGONISTS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PYRAZOLES
PYRAZOLINES
RODENTS
SEPARATION PROCESSES
THIOUREAS
USES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics