Primary hepatocytes in monolayer culture: a model for studies on lipoprotein metabolism
Journal Article
·
· Annu. Rev. Physiol.; (United States)
The pioneering studies of Berry and Friend on isolation of hepatocytes and that of Bissel et al on culturing hepatocytes in nonproliferating monolayers demonstrated the feasibility of using isolated parenchymal cells to study functional aspects of the liver. The obvious advantage of such a system is that one can study metabolic events in a defined, easily manipulated population of cells for periods of hours or even days. This review focuses on nonproliferating hepatic parenchymal cells in monolayer culture as a model for investigating lipoprotein synthesis and degradation. 60 references, 1 table.
- Research Organization:
- Univ. of California, Berkeley
- OSTI ID:
- 6389736
- Journal Information:
- Annu. Rev. Physiol.; (United States), Vol. 46
- Country of Publication:
- United States
- Language:
- English
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