skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Carbon monoxide exposure of subjects with documented cardiac arrhythmias. Research report, August 1987-July 1991

Abstract

The authors studied 30 subjects with well-documented coronary artery disease who had an average of at least 30 ventricular ectopic beats per hour over a 20-hour monitoring interval. Subjects were selected and enrolled in a randomized double-blind study; the carbon monoxide exposure was designed to result in 3% or 5% carboxyhemoglobin levels, as measured by gas chromatography. Total and repetitive ventricular arrhythmias were measured for four specific time intervals: (1) two hours before carbon monoxide exposure; (2) during the two-hour carbon monoxide exposure; (3) six hours after carbon monoxide exposure; and (4) approximately 10 hours after exposure, or the remaining recording interval on the Holter monitor. There was no increase in ventricular arrhythmia frequency after carbon monoxide exposure, regardless of the level of carboxyhemoglobin or the type of activity. During steady-state conditions at rest, the number of ventricular ectopic beats per hour was 115 + or - 153 (SD) for room air exposure (0.7% carboxyhemoglobin), 121 + or - 171 for the lower carbon monoxide exposure (3.2% carboxyhemoglobin), and 94 + or - 129 for the higher carbon monoxide exposure (5.1% carboxyhemoglobin). The frequency of complex ventricular ectopy was not altered at the levels of carbon monoxide studied. Secondary analysismore » of the impact of carbon monoxide on ventricular ectopic beat frequency stratified by baseline ejection fraction, baseline ventricular ectopic beat frequency, and exercise-induced ST-segment changes did not indicate an effect of carbon monoxide on ventricular arrhythmias. However, patients with symptomatic ventricular arrhythmias and symptomatic myocardial ischemia were excluded from the present study.« less

Authors:
; ; ; ;
Publication Date:
Research Org.:
Saint Louis Univ., MO (United States). School of Medicine
OSTI Identifier:
6374196
Report Number(s):
PB-93-179943/XAB
Resource Type:
Technical Report
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CARBON MONOXIDE; HEALTH HAZARDS; CARBOXYHEMOGLOBIN; MONITORING; CARDIOVASCULAR DISEASES; AIR POLLUTION; GAS CHROMATOGRAPHY; PATIENTS; RANDOMNESS; RESEARCH PROGRAMS; STATISTICAL DATA; STEADY-STATE CONDITIONS; CARBON COMPOUNDS; CARBON OXIDES; CHALCOGENIDES; CHROMATOGRAPHY; DATA; DISEASES; HAZARDS; INFORMATION; NUMERICAL DATA; OXIDES; OXYGEN COMPOUNDS; POLLUTION; SEPARATION PROCESSES; 560300* - Chemicals Metabolism & Toxicology

Citation Formats

Chaitman, B R, Dahms, T E, Byers, S, Carroll, L W, and Younis, L T. Carbon monoxide exposure of subjects with documented cardiac arrhythmias. Research report, August 1987-July 1991. United States: N. p., 1992. Web.
Chaitman, B R, Dahms, T E, Byers, S, Carroll, L W, & Younis, L T. Carbon monoxide exposure of subjects with documented cardiac arrhythmias. Research report, August 1987-July 1991. United States.
Chaitman, B R, Dahms, T E, Byers, S, Carroll, L W, and Younis, L T. 1992. "Carbon monoxide exposure of subjects with documented cardiac arrhythmias. Research report, August 1987-July 1991". United States.
@article{osti_6374196,
title = {Carbon monoxide exposure of subjects with documented cardiac arrhythmias. Research report, August 1987-July 1991},
author = {Chaitman, B R and Dahms, T E and Byers, S and Carroll, L W and Younis, L T},
abstractNote = {The authors studied 30 subjects with well-documented coronary artery disease who had an average of at least 30 ventricular ectopic beats per hour over a 20-hour monitoring interval. Subjects were selected and enrolled in a randomized double-blind study; the carbon monoxide exposure was designed to result in 3% or 5% carboxyhemoglobin levels, as measured by gas chromatography. Total and repetitive ventricular arrhythmias were measured for four specific time intervals: (1) two hours before carbon monoxide exposure; (2) during the two-hour carbon monoxide exposure; (3) six hours after carbon monoxide exposure; and (4) approximately 10 hours after exposure, or the remaining recording interval on the Holter monitor. There was no increase in ventricular arrhythmia frequency after carbon monoxide exposure, regardless of the level of carboxyhemoglobin or the type of activity. During steady-state conditions at rest, the number of ventricular ectopic beats per hour was 115 + or - 153 (SD) for room air exposure (0.7% carboxyhemoglobin), 121 + or - 171 for the lower carbon monoxide exposure (3.2% carboxyhemoglobin), and 94 + or - 129 for the higher carbon monoxide exposure (5.1% carboxyhemoglobin). The frequency of complex ventricular ectopy was not altered at the levels of carbon monoxide studied. Secondary analysis of the impact of carbon monoxide on ventricular ectopic beat frequency stratified by baseline ejection fraction, baseline ventricular ectopic beat frequency, and exercise-induced ST-segment changes did not indicate an effect of carbon monoxide on ventricular arrhythmias. However, patients with symptomatic ventricular arrhythmias and symptomatic myocardial ischemia were excluded from the present study.},
doi = {},
url = {https://www.osti.gov/biblio/6374196}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Sep 01 00:00:00 EDT 1992},
month = {Tue Sep 01 00:00:00 EDT 1992}
}

Technical Report:
Other availability
Please see Document Availability for additional information on obtaining the full-text document. Library patrons may search WorldCat to identify libraries that may hold this item. Keep in mind that many technical reports are not cataloged in WorldCat.

Save / Share: