Treatment of stage D bladder cancer with adjuvant doxorubicin hydrochloride and radiation
pathologic Stage D bladder cancer was recognized in 16 patients by evaluation tissue obtained by radical cystectomy and pelvic lymphadenectomy (7), pelvic lymph node dissection (3) or biopsies (3), ileal conduit and pelvic lymph node biopsy (1), or transurethral biopsy of the bladder and prostate (2). Treatment of these patients with radiation preceded and followed by doxorubicin hydrochloride (Adriamycin) was initiated three to four weeks postoperatively. The treatment regimen consisted of the following: (1) doxorubicin 60 mg/M2 intravenously every three weeks for three cycles; (2) 5,000 rad external radiation to the whole pelvis in five to six weeks; and (3) doxorubicin for five cycles. The mean survival was twenty-three months. The survival rate was as follows: one year, 10 of 15 patients at risk; two years, 6 of 11; three years, 5 of 9; four years, 1 of 4; and five years, 0 of 2. Ten patients died six to thirty-six months (mean 13.6) postoperatively. In 6 of the patients significant obstruction of small bowel developed. These preliminary observations indicate encouraging therapeutic results with an acceptable morbidity for this regimen.
- Research Organization:
- Department of Urology, The McGaw Medical Center of Northwestern University, Chicago, Illinois
- OSTI ID:
- 6374114
- Journal Information:
- Urology (Ridgewood, N.J.); (United States), Vol. 20:4
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
BLADDER
BIOLOGICAL RADIATION EFFECTS
CARCINOMAS
RADIOTHERAPY
SIDE EFFECTS
DOXORUBICIN
FRACTIONATED IRRADIATION
LOCAL IRRADIATION
PATIENTS
RADIATION DOSES
RADIOSENSITIVITY EFFECTS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTINEOPLASTIC DRUGS
BIOLOGICAL EFFECTS
BODY
DISEASES
DOSES
DRUGS
IRRADIATION
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
RADIATION EFFECTS
RADIOLOGY
THERAPY
URINARY TRACT
550603* - Medicine- External Radiation in Therapy- (1980-)
560151 - Radiation Effects on Animals- Man
550900 - Pathology