Lung function and morphology of dogs after sublethal exposure to nitrogen dioxide

Journal Article · Sun Aug 01 00:00:00 EDT 1982 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398209530244· OSTI ID:6373608

Johnson, W K; Mauderly, J L; Hahn, F F; Muggenburg, B A

The relationship between respiratory function and morphological changes in 10 dogs exposed for 6 h to 69 ppm nitrogen dioxide was studied. Two additional dogs served as controls. Functional assessments included breathing pattern, breathing mechanics, forced expiration, gas exchange, and acid-base status. Gross, microscopic, and ultrastructural evaluations were made of lung tissues from dogs killed at 0.1, 1.0, 2.0, 3.0, 7.0 and 14.0 d after exposure. Functional changes were similar to those reported for man. The principal dysfunction was gas-exchange impairment, apparently resulting from foam in the airways. Breathing-pattern alterations appeared to result from stimulation of neural receptors. Gas-exchange measurements provided the most useful indicators of the pulmonary damage observed in this study.

• DOE Contract Number: AC04-76EV01013
• OSTI ID: 6373608
• Journal Information: J. Toxicol. Environ. Health; (United States), Vol. 10:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LUNGS
BIOLOGICAL FUNCTIONS
ULTRASTRUCTURAL CHANGES
NITROGEN DIOXIDE
BIOLOGICAL EFFECTS
BREATH
CENTRAL NERVOUS SYSTEM
DOGS
RECEPTORS
RESPIRATION
ANIMALS
BODY
CHALCOGENIDES
FUNCTIONS
MAMMALS
MORPHOLOGICAL CHANGES
NERVOUS SYSTEM
NITROGEN COMPOUNDS
NITROGEN OXIDES
ORGANS
OXIDES
OXYGEN COMPOUNDS
RESPIRATORY SYSTEM
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)