Direct measure of the destruction of bone marrow cells, after their injection into variously pretreated syngeneic hosts
/sup 125/IUdR-labeled bone marrow cells have been injected into syngeneic mice and their destruction measured by counting daily the animals in toto in a gamma counter. In lethally irradiated recipients, the immediate cell loss was the greatest when the irradiation was delivered just prior to the cell transfer and the cellular multiplication in the spleen on day 7, the smallest. The slopes of the destruction between days 1 and 4 are closely comparable, whether the animals were irradiated 45, 21, or 4 hr before the cell transfer. The immediate cell loss was greater in untreated animals than in the cyclophosphamide-treated recipients and the slope of the destruction curve was higher in cyclophosphamide-treated than in untreated animals. The intensity of the restoration measured by the /sup 125/IUdR and /sup 59/Fe incorporation on day 6 is inversely correlated to the intensity of the early destruction.
- Research Organization:
- Hopital Universitaire Paul-Brousse, Institut de Cancerologie et d'Immunogenetique, Villejuif, France
- OSTI ID:
- 6372063
- Journal Information:
- Transplantation; (United States), Vol. 34:4
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
BONE MARROW CELLS
BIOLOGICAL RADIATION EFFECTS
IODINE 125
ISOTOPE APPLICATIONS
IRON 59
ENDOXAN
EXTERNAL IRRADIATION
LABELLED COMPOUNDS
MICE
SURVIVAL CURVES
ALKYLATING AGENTS
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
CONNECTIVE TISSUE CELLS
DAYS LIVING RADIOISOTOPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
IMMUNOSUPPRESSIVE DRUGS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
IRON ISOTOPES
IRRADIATION
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
RADIATION EFFECTS
RADIOISOTOPES
RODENTS
SOMATIC CELLS
VERTEBRATES
560151* - Radiation Effects on Animals- Man
550301 - Cytology- Tracer Techniques
551001 - Physiological Systems- Tracer Techniques