Retention of ingested latex particles in Peyer's patches of germ-free and conventional mice
Conventional and germ-free mice ingested a suspension of 2-..mu..m latex particles in drinking water for a 15-day period. Number and distribution of intestinal Peyer's patches did not differ significantly in the two types of mice. Cleared Peyer's patches were compared with regard to size and particle content. The location of particles within Peyer's patch follicles of germ-free mice was similar to that of conventional mice, but the latter had significantly larger follicles and greater accumulations of latex particles. Latex concentration varied with patch location. Proximal patches contained the majority of particles in germ-free mice, whereas particles were most abundant in distal patches of conventional mice. The results show that particle uptake into Peyer's patches takes place even in the complete absence of bacteria in the gut.
- Research Organization:
- Brookhaven National Lab., Upton, NY
- DOE Contract Number:
- AC02-76CH00016
- OSTI ID:
- 6371739
- Journal Information:
- Proc. Soc. Exp. Biol. Med.; (United States), Vol. 179:4
- Country of Publication:
- United States
- Language:
- English
Similar Records
M cells and granular mononuclear cells in Peyer's patch domes of mice depleted of their lymphocytes by total lymphoid irradiation
Depletion and repopulation of lymphocytes in Peyer's patches of mice after total lymphoid irradiation
Related Subjects
LATEX
BIOLOGICAL ACCUMULATION
RETENTION
TISSUE DISTRIBUTION
PARTICULATES
UPTAKE
BACTERIA
DRINKING WATER
EXPERIMENTAL DATA
INGESTION
INTESTINES
LYMPHATIC SYSTEM
MICE
ANIMALS
BODY
DATA
DIGESTIVE SYSTEM
DISTRIBUTION
ELASTOMERS
GASTROINTESTINAL TRACT
HYDROGEN COMPOUNDS
INFORMATION
INTAKE
MAMMALS
MICROORGANISMS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC POLYMERS
ORGANS
OXYGEN COMPOUNDS
PARTICLES
POLYMERS
RODENTS
RUBBERS
VERTEBRATES
WATER
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)