Effects of ClO/sub 2/ on the absorption and distribution of dietary iodide in the rat
Aqueous chlorine dioxide, an alternative disinfectant for drinking water, was found to decrease gastrointestinal (GI) bioavailability of dietary iodide. It has been previously reported that subchronic exposure to ClO/sub 2/ decreases thyroxine (T4) levels in nonhuman primates. In this study in vitro experiments with animal feed, isolated rat stomachs, as well as in vivo studies with intact rats, showed that ClO/sub 2/ in drinking water (at in situ concentrations as low as 2 ppm) oxidizes iodide to its reactive elemental (radical) state, binding it to organic substances present in the GI tract. A single instance of acute exposure to ClO/sub 2/, however, did not decrease blood iodide levels, or thyroid glandular uptake of iodine.
- Research Organization:
- Univ. of Cincinnati Medical Center, OH
- OSTI ID:
- 6371731
- Journal Information:
- Fundam. Appl. Toxicol.; (United States), Vol. 4
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CHLORINE COMPOUNDS
BIOLOGICAL EFFECTS
IODIDES
INTESTINAL ABSORPTION
TISSUE DISTRIBUTION
ANIMAL FEEDS
BIOLOGICAL AVAILABILITY
DIET
DRINKING WATER
IN VITRO
IN VIVO
OXIDES
RATS
STOMACH
ABSORPTION
ANIMALS
BODY
CHALCOGENIDES
DIGESTIVE SYSTEM
DISTRIBUTION
FOOD
GASTROINTESTINAL TRACT
HALIDES
HALOGEN COMPOUNDS
HYDROGEN COMPOUNDS
IODINE COMPOUNDS
MAMMALS
ORGANS
OXYGEN COMPOUNDS
RODENTS
UPTAKE
VERTEBRATES
WATER
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)