Some factors influencing salivary function when treating with radiotherapy

Journal Article · Wed Apr 01 00:00:00 EST 1981 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(81)90140-1· OSTI ID:6363727

Mira, J G; Wescott, W B; Starcke, E N; Shannon, I L

Salivary flow rate was studied in 29 patients treated with external irradiation to head and neck areas. Resting saliva samples were collected before, during the radiotherapy course and follow-up. Several parameters were investigated: field arrangement, amount of salivary glands irradiated, dose to these glands, initial FR, its recovery during and after irradiation, and influence of therapy interruption in FR. It was found that the level of the upper border of the field is a critical factor when using parallel-opposed lateral fields to the upper neck area and lateral face. More than 50% of the parotids have to be outside the fields to prevent severe dryness. Neck fields which do not encompass salivary glands do not decrease salivary secretion. There is some relation between the initial FR and the dose necessary to produce dryness: patients with high initial salivary FR require higher doses. FR recovery occurs during weekend interruptions before xerostomia develops. Interruptions of therapy for more than two weeks during the radiotherapy course prior to development of dryness might decrease late xerostomia, at least in patients with high initial FR. Objective recovery of the FR has not been observed after treatment in spite of the subjective improvement in the sensation of dryness of some patients.

• Research Organization: Veterans Administration Medical Center, Houston, TX
• OSTI ID: 6363727
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 7:4
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
RADIOTHERAPY
SIDE EFFECTS
SALIVARY GLANDS
BIOLOGICAL RADIATION EFFECTS
DYNAMIC FUNCTION STUDIES
EXTERNAL IRRADIATION
HEAD
NECK
NEOPLASMS
PATIENTS
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RADIATION INJURIES
SALIVA
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
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DOSES
GLANDS
INJURIES
IRRADIATION
MATERIALS
MEDICINE
NUCLEAR MEDICINE
ORGANS
RADIATION EFFECTS
RADIOLOGY
THERAPY
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