Drug-induced modulation of Tc-99m pyrophosphate tissue distribution: what is involved
More than ten years after their introduction, Tc-99m-labeled phosphates and phosphonates (TcP) continue to be of interest to the investigator and to hold promise for new clinical applications in the future. Initially, TcP compounds were valued because of their bone-seeking properties. Emphasis shifted from bone to soft tissue when Bonte et al. introduced Tc-99m-labeled pyrophosphate (TcPPi) for myocardial infarct scanning. Detailed information about TcPPi uptake in ischemic and necrotic myocardial tissue at the subcellular level has accumulated. Therefore, understanding of the mechanism of TcPPi uptake in infarcted myocardium is more detailed than understanding of uptake by bone. A new, and potentially powerful, approach to the use of TcP is being proposed by Carr et al. The authors attempt to modulate favorably the tissue distribution of TcPPi by prior administration of drugs in pharmacological quantities. The authors demonstrate that uptake of TcPPi can be enhanced in the necrotic myocardium, uptake by bone can be reduced, and the lesion-to-blood ratio can be altered favorably when vitamin D/sub 3/ or desoxycorticosterone acetate (DOCA) is administered in pharmacological doses before the TcPPi injection. A short review is presented of background information helpful for interpreting the drug effects on TcPPi uptake in bone or necrotic myocardial tissue.
- Research Organization:
- Mayo Clinic, Rochester, MN
- OSTI ID:
- 6363405
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 22:6; Conference: 28. Society of Nuclear Medicine annual meeting, Las Vegas, NV, USA, 16 Jun 1981
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
CHOLECALCIFEROL
BIOLOGICAL EFFECTS
DOCA
RADIOPHARMACEUTICALS
TISSUE DISTRIBUTION
ISOMERIC NUCLEI
MYOCARDIUM
PHOSPHONATES
PYROPHOSPHATES
SKELETON
TECHNETIUM 99
UPTAKE
ADRENAL HORMONES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR SYSTEM
CORTICOSTEROIDS
DISTRIBUTION
DRUGS
HEART
HORMONES
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KETONES
LABELLED COMPOUNDS
MINERALOCORTICOIDS
MUSCLES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PHOSPHORUS COMPOUNDS
PREGNANES
RADIOISOTOPES
STEROID HORMONES
STEROIDS
TECHNETIUM ISOTOPES
VITAMIN D
VITAMINS
YEARS LIVING RADIOISOTOPES
560171* - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987)
550601 - Medicine- Unsealed Radionuclides in Diagnostics