In-depth survey report: control technology assessment of enzyme fermentation processes at Miles Laboratories, Inc. , Elkhart, Indiana

Technical Report · Wed Oct 01 00:00:00 EDT 1986

OSTI ID:6357872

Sheehy, J W; Martinez, K F

The controls and containment capabilities of the carbohydrase enzyme manufacturing process were evaluated at the Miles Laboratories, Inc. facility located in Elkhart, Indiana. The enzyme alpha-amylase has been produced at this facility since March of 1982. One specific unit process showed results significantly above the background levels, that being the centrifuge. At the vacuum-filter knife edge, the viable levels were higher than background, but even within a few feet of the vacuum-filter belt they were reduced below background levels. Levels were not significantly above background at the fermentor agitator shaft, seed fermentor agitator shaft, and fermentor sample port. The clean room had background levels significantly below the levels in the laboratory. Apparently the overall effective containment of the production organisms used is very good. Measures of total dust levels indicated these were far below the threshold limit value of 10mg/cu m.

• Research Organization: National Inst. for Occupational Safety and Health, Cincinnati, OH (USA)
• OSTI ID: 6357872
• Report Number(s): PB-87-164463/XAB; ECTB-116-166
• Country of Publication: United States
• Language: English

Related Subjects

54 ENVIRONMENTAL SCIENCES
99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE
AMYLASE
INDOOR AIR POLLUTION
CHEMICAL INDUSTRY
DRUGS
HAZARDOUS MATERIALS
DUSTS
MICROORGANISMS
CONTAINMENT
OCCUPATIONAL SAFETY
AIR POLLUTION
ANTIBIOTICS
ENZYMES
INDUSTRIAL MEDICINE
INSPECTION
TOXICITY
ANTI-INFECTIVE AGENTS
GLYCOSYL HYDROLASES
HYDROLASES
INDUSTRY
MATERIALS
MEDICINE
O-GLYCOSYL HYDROLASES
POLLUTION
SAFETY
500200* - Environment
Atmospheric- Chemicals Monitoring & Transport- (-1989)
552000 - Public Health