Role of organic volatile profiles in clinical diagnosis
- Univ. of Houston, TX
The organic volatile constituents of biological fluids contain clinically useful diagnostic information for the recognition of metabolic disorders in man. To gain access to this information, it was necessary to develop the methodology for reproducibly stripping the trace concentrations of volatiles from biological fluids (dynamic headspace, gas phase-stripping, solvent extraction, and the transevaporator technique), to separate the complex extracts by high-resolution capillary column gas chromatography, and to develop computer-aided data-handling and pattern-recognition techniques for analyzing the immense amount of information generated. The normal and pathological organic volatiles identified by gas chromatography-mass spectrometry in urine, serum, and breast milk are tabulated. Clinical applications of the above techniques to the study and diagnosis of diabetes mellitus, respiratory virus infection, renal insufficiency, and cancer are described.
- OSTI ID:
- 6356706
- Journal Information:
- Clin. Chem. (Winston-Salem, N.C.); (United States), Vol. 27:6; Conference: 33. national AACC meeting, Kansas City, MO, USA, 19 July 1981
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
DIABETES MELLITUS
DIAGNOSIS
METABOLIC DISEASES
NEOPLASMS
QUANTITATIVE CHEMICAL ANALYSIS
DIAGNOSTIC USES
RESPIRATORY SYSTEM DISEASES
VIRAL DISEASES
ALCOHOLS
ALDEHYDES
BLOOD SERUM
GAS CHROMATOGRAPHY
HETEROCYCLIC COMPOUNDS
KETONES
MASS SPECTROSCOPY
MILK
PATIENTS
SULFIDES
THIOLS
URINE
VOLATILITY
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CHALCOGENIDES
CHEMICAL ANALYSIS
CHROMATOGRAPHY
DISEASES
ENDOCRINE DISEASES
FOOD
HYDROXY COMPOUNDS
INFECTIOUS DISEASES
MATERIALS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
SEPARATION PROCESSES
SPECTROSCOPY
SULFUR COMPOUNDS
USES
WASTES
550600* - Medicine
550200 - Biochemistry