Quantitative study of fluoride transport during subsurface dissolution of dental enamel
Previous studies using bovine dental enamel as a model have shown that surface and subsurface dissolution of enamel may be governed by micro-environmental solution conditions. We have now investigated the demineralization phenomenon more rigorously with the primary objective of developing a method for deducing solution species concentration profiles as a function of time from appropriate experimental data. More specifically, in this report, a model-independent method is described for determination of the pore solution fluoride gradients in bovine enamel during subsurface demineralization. Microradiography was used to determine the mineral density profiles, and an electron microprobe technique to determine total fluoride (F) profiles associated with the enamel. In each case, matched sections of bovine enamel were exposed to partially saturated acetate buffers at pH = 4.5 containing 0.5 ppm F for various periods of time (from six to 24 hours). The treated enamel was found to have an intact surface layer and subsurface demineralization. The extent of the demineralization and the depths of the lesions increased with time in all cases. The data were first used to calculate (a) the total F gradients in the enamel at various times, and (b) the local uptake rate of F as a function of time and position. Then, by manipulation of the equations describing the uptake and transport of F, we calculated the pore diffusion rate of F and the micro-environmental solution F concentration in the aqueous pores as a function of time and of distance from the enamel surface. It was also possible to calculate an intrinsic F diffusion coefficient in the pores, which was about 1.0 X 10(-5) cm2/sec, in good agreement with reported values.
- Research Organization:
- Univ. of Utah, Salt Lake City (USA)
- OSTI ID:
- 6354359
- Journal Information:
- J. Dent. Res.; (United States), Vol. 68:1
- Country of Publication:
- United States
- Language:
- English
Similar Records
In vitro effect of amorphous calcium phosphate paste applied for extended periods of time on enamel remineralization
Bovine dental fluorosis: histologic and physical characteristics
Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
ENAMELS
MINERALIZATION
FLUORIDES
MEMBRANE TRANSPORT
BIOMEDICAL RADIOGRAPHY
CARBON 14 COMPOUNDS
CARIES
CATTLE
DENSITY
DENTISTRY
DISSOLUTION
ELECTRON MICROPROBE ANALYSIS
MATHEMATICAL MODELS
MINERALS
TEETH
TRACER TECHNIQUES
ANIMALS
CHEMICAL ANALYSIS
COATINGS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DOMESTIC ANIMALS
FLUORINE COMPOUNDS
HALIDES
HALOGEN COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MEDICINE
MICROANALYSIS
NUCLEAR MEDICINE
ORAL CAVITY
PATHOLOGICAL CHANGES
PHYSICAL PROPERTIES
RADIOLOGY
RUMINANTS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques
550602 - Medicine- External Radiation in Diagnostics- (1980-)