Nuclear medicine program: Progress report for quarter ending March 31, 1988
In this report the results of several studies with radioiodinated fatty acid are described. Studies with the isolated Langendorff- perfused rat heart system have continued to evaluate the distribution of (I-125)-15-(p-iodophenyl)-3-R,S-methylpentadecanoic acid (BMIPP) in myocardial lipids after 15 min of perfusion. At this time period 38--44% of the endogenous radioactivity is associated with material chromatographing in the region of triglycerides, 18--21% in the region of diglycerides and only 6--10% in the area of free fatty acids. Thus, the isolated heart mimics the in vivo studies in demonstrating that the retention of radioiodinated BMIPP is associated with lipid storage products. In addition, the synthesis of the isomeric mixture of 9- and 10-(I-125)-labeled iodooleic acid via formation of the corresponding a boronic acid intermediate is also described. The isomeric radioiodinated product mixture shows good heart uptake and retention (5 min, 3.45% dose/gm; 30 min, 2.44% dose/gm; 60 min, 2.28% dose/gm) and demonstrate that this structural perturbation does not interfere with myocardial specificity.
- Research Organization:
- Oak Ridge National Lab., TN (USA)
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 6353730
- Report Number(s):
- ORNL/TM-10839; ON: DE89007920
- Resource Relation:
- Other Information: Portions of this document are illegible in microfiche products
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
MONOCARBOXYLIC ACIDS
IODINATION
RADIOPHARMACEUTICALS
SYNTHESIS
CHELATING AGENTS
COPPER 64
COPPER 67
HEART
LABELLING
MEDICAL PERSONNEL
METABOLITES
MONOCLONAL ANTIBODIES
NUCLEAR MEDICINE
ORNL
PROGRESS REPORT
PURIFICATION
RADIOBIOLOGY
RADIOCHEMISTRY
RATS
RHENIUM 186
RHENIUM 188
TRAINING
ANIMALS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGY
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CHEMICAL REACTIONS
CHEMISTRY
COPPER ISOTOPES
DAYS LIVING RADIOISOTOPES
DOCUMENT TYPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HALOGENATION
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MEDICINE
MINUTES LIVING RADIOISOTOPES
NATIONAL ORGANIZATIONS
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PERSONNEL
RADIOISOTOPES
RHENIUM ISOTOPES
RODENTS
US AEC
US DOE
US ERDA
US ORGANIZATIONS
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
400703 - Radiochemistry & Nuclear Chemistry- Radioisotope Production