Effect of acute nitrogen dioxide exposure on the composition of fatty acid associated with phospholipids in alveolar lavage

Journal Article · Sun Jan 01 00:00:00 EST 1984 · Chemosphere; (United States)

DOI:https://doi.org/10.1016/0045-6535(84)90012-2· OSTI ID:6352300

Kobayashi, T; Noguchi, T; Kikuno, M; Kubota, K

In vivo exposure of rats to 10 ppm nitrogen dioxide (NO/sub 2/) for 12 h caused changes in fatty acids composition of alveolar lavage phospholipids. Among the fatty acid species, the relative ratio of palmitic acid, myristic acid and palmitoleic acid increased significantly. While the relative ratio of stearic acid, oleic acid, linoleic acid and arachidonic acid decreased significantly. Both the increase in the incorporation of palmitic acid in phosphatidylcholine which would be released into the alveoli and the increase in the release of phosphatidylcholine into the alveoli may account for the changes in the fatty acid composition of the present findings.

• Research Organization: National Inst. for Environmental Studies, Tsukuba, Ibaraki, Japan
• OSTI ID: 6352300
• Journal Information: Chemosphere; (United States), Vol. 13:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CARBOXYLIC ACIDS
BIOCHEMISTRY
NITROGEN DIOXIDE
BIOLOGICAL EFFECTS
ARACHIDONIC ACID
HEXADECANOIC ACID
IN VIVO
LAVAGE
LINOLEIC ACID
LUNGS
OCTADECANOIC ACID
OLEIC ACID
PHOSPHOLIPIDS
RATS
TETRADECANOIC ACID
ANIMALS
BODY
CHALCOGENIDES
CHEMISTRY
ESTERS
LIPIDS
MAMMALS
MONOCARBOXYLIC ACIDS
NITROGEN COMPOUNDS
NITROGEN OXIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)