Respiratory clearance of aerosolized radioactive solutes of varying molecular weight

Journal Article · Fri May 01 00:00:00 EDT 1987 · J. Nucl. Med.; (United States)

OSTI ID:6351587

Huchon, G J; Montgomery, A B; Lipavsky, A; Hoeffel, J M; Murray, J F

To determine the influence of varying molecular weight (mol wt) on respiratory clearance of aerosolized solutes, we studied eight radiopharmaceuticals, each administered to four dogs: sodium /sup 99m/Tc pertechnetate (TcO4), /sup 99m/Tc glucoheptonate ((/sup 99m/Tc)GH), 51Cr-ethylenedinitrotetraacetate ((51Cr)EDTA), /sup 99m/Tc diethylenetriaminepentaacetate ((99mTc) DTPA), /sup 111/In diethylenetriaminepentaacetate ((/sup 111/In)DTPA), /sup 67/Ga desferoxaminemesylate ((/sup 67/Ga)DFOM), /sup 99m/Tc dextran ((/sup 99m/Tc)DX) and /sup 111/In transferrin ((/sup 111/In)TF). After aerosolization (0.8 m MMD, 2.4 GSD), clearance was determined for 30 min and then corrected by intravenous injection for nonairspace radioactivity. In-TF clearance (0.11 +/- 0.10%/min) was lower than TcO4 (6.32 +/- 0.62%/min), (/sup 99m/Tc)GH (1.50 +/- 0.37%/min), (/sup 51/Cr)EDTA (2.38 +/- 1.02%/min), (/sup 99m/Tc)DTPA (3.51 +/- 0.40%/min), (/sup 111/In)DTPA (2.35 +/- 0.42%/min), (/sup 67/Ga) DFOM (1.99 +/- 0.49%/min) and (/sup 99m/Tc)DX (1.81 +/- 0.75%/min) clearances (p less than 0.001). TcO4 clearance was higher than others (p less than 0.001). Technetium binding to DX was unsatisfactory; aerosolization caused unbinding from DTPA. We conclude that respiratory clearance of large mol wt solutes within 30 min is negligible and, that clearance of molecules between 347-5099 daltons differs greatly, suggesting that binding and/or intrapulmonary retention affect transfer.

• Research Organization: Universite Rene Descartes, Paris, France
• OSTI ID: 6351587
• Journal Information: J. Nucl. Med.; (United States), Vol. 5
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LUNGS
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
LUNG CLEARANCE
CHROMIUM 51
DEFEROXAMINE
DOGS
DTPA
EDTA
GALLIUM 67
INDIUM 111
ISOMERIC NUCLEI
MOLECULAR WEIGHT
RADIOACTIVE AEROSOLS
TECHNETIUM 99
TRANSFERRIN
AEROSOLS
AMINES
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CHELATING AGENTS
CHROMIUM ISOTOPES
CLEARANCE
COLLOIDS
DAYS LIVING RADIOISOTOPES
DISPERSIONS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
EXCRETION
GALLIUM ISOTOPES
GLOBULINS
GLOBULINS-BETA
HOURS LIVING RADIOISOTOPES
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
METALLOPROTEINS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RESPIRATORY SYSTEM
SOLS
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560162* - Radionuclide Effects
Kinetics
& Toxicology- Animals
Plants
Microorganisms
& Cells