Histopathology of CNS leukemia and complications of therapy
An understanding of the pathology of central nervous system (CNS) leukemia has evolved slowly. Although infiltration of the leptomeninges by leukemic cells remains the principal CNS lesion in patients with this disease, other histopathologic changes have become evident with the development of antileukemic therapy. Only recently, following effective control of CNS leukemia with chemotherapy and irradiation, did it become clear that current methods of treatment can produce neurotoxic effects. Two specific examples are leukoencephalopathy and mineralizing microangiopathy, both apparently induced by the effects of radiation on the microvasculature. These results will permit sounder judgments of whether the risks of CNS radiotherapy outweigh the known benefits.
- Research Organization:
- St. Jude Children's Research Hospital, Memphis, TN
- OSTI ID:
- 6341536
- Journal Information:
- Am. J. Pediatr. Hematol./Oncol.; (United States), Vol. 1:1
- Country of Publication:
- United States
- Language:
- English
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BLOOD VESSELS
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