In vivo quantitation of regional myocardial blood flow by positron-emission computed tomography. [Dogs; /sup 68/Ga; /sup 141/Ce]

Journal Article · Mon Jun 01 00:00:00 EDT 1981 · Circulation; (United States)

DOI:https://doi.org/10.1161/01.CIR.63.6.1248· OSTI ID:6337966

Wisenberg, G; Schelbert, H R; Hoffman, E J; Phelps, M E; Robinson, Jr, G D; Selin, C E; Child, J; Skorton, D; Kuhl, D E

The potential of positron-emission computed tomography (PCT) for external quantitation of myocardial indicator concentrations and regonal myocardial blood flow (RMBF) and the effect of left ventricular wall thickness on tracer concentration recovery by PCT was examined in seven open-chest dogs. RMBF was determined by the arterial reference technique in vivo and in vitro. Together with gamma-emitting Ce-141 microspheres, positron-emitting Ga-68-labeled microspheres were injected into the left atrium and their myocardial concentrations determined in vivo from gated and ungated cross-sectional PCT images. It is concluded that (1) myocardial indicator tissue concentrations, and thus, RMBF, can be accurately measured by PCT provided corrections are made for the effect of wall thickness on count recovery; (2) these corrections can be made using in vivo echocardiography; and (3) gated PCT imaging can be used to evaluate regional myocardial systolic wall thickening as an index of regional function and combined with measurements of RMBF or regional metabolism. The results represent a framework for the noninvasive measurement of RMBF and metabolism by PCT in the experimental animal and in man.

• Research Organization: Univ. of California, Los Angeles, CA (United States)
• DOE Contract Number: AM06-76-SF000012
• OSTI ID: 6337966
• Journal Information: Circulation; (United States), Vol. 63:6
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BLOOD FLOW
MEASURING METHODS
CERIUM 141
POSITRON COMPUTED TOMOGRAPHY
GALLIUM 68
MYOCARDIUM
DIAGNOSTIC USES
DOGS
IN VIVO
MICROSPHERES
RADIOPHARMACEUTICALS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR SYSTEM
CERIUM ISOTOPES
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
GALLIUM ISOTOPES
HEART
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MUSCLES
NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIOISOTOPES
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
TOMOGRAPHY
USES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics