Medulloblastoma in childhood: long-term results of treatment. [X rays; /sup 60/Co]
Thirty-one children under the age of 15 years with verified medulloblastoma were treated at Addenbrookes Hospital from 1940 to 1976. In addition to surgical treatment, all received high dose irradiation to the whole neuraxis. Nine were still alive in 1979, of whom eight were examined. All these patients showed some residual problems, but five were leading active lives and had only minor physical disability. There was evidence of disturbance in growth in all the children. Growth hormone secretion in response to exercise was, however, normal in five of six patients tested. Frank mental retardation was present in three children. A raised resing TSH level was found in two children, one of whom had a multinodular goiter. Long-term follow-up of children who survive medulloblastoma is clearly necessary and consideration should perhaps be given to revision of current treatment regimes in very young children.
- Research Organization:
- Addenbrookes Hospital, Cambridge, England
- OSTI ID:
- 6337305
- Journal Information:
- Cancer; (United States), Vol. 48:1
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
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RADIOINDUCTION
RADIOTHERAPY
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STH
TSH
VERTEBRAE
ANIMAL GROWTH
BRAIN
CHILDREN
COBALT 60
GAMMA RADIATION
NEOPLASMS
PATIENTS
SURGERY
X RADIATION
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BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
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DISEASES
ELECTROMAGNETIC RADIATION
GROWTH
HORMONES
INTERMEDIATE MASS NUCLEI
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IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
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MEDICINE
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NUCLEAR MEDICINE
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ODD-ODD NUCLEI
ORGANS
PEPTIDE HORMONES
PITUITARY HORMONES
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RADIATIONS
RADIOISOTOPES
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SKELETON
SKULL
THERAPY
YEARS LIVING RADIOISOTOPES
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